Banyu Pharmaceutical Co. Ltd

Yoshiaki Iida

Yoshikazu Iwasawa

Masahiro Hayashi

Morihiro Mitsuya

Katsumasa Nonoshita

Takashi Nomoto

Yasufumi Nagata

Masaaki Hosoi

Toshio Kamei

Kenji Niiyama

Yoshimi Tsuchiya

Yusuke Hidaka

Hiroshi Takeshita

Hiroshi Takezawa

Masahiro Horie

Yoshio Hioki

Ryo Nishioka

A compound of the formula (I) or its pharmaceutically acceptable salt or ester: ##STR1## wherein each of ##STR2## which are the same or different, is an aryl group or a heteroaromatic ring group; A is a C.sub.3-8 linear saturated or unsaturated aliphatic hydrocarbon group which may have substituent(s) selected from the group consisting of a lower alkyl group, a hydroxyl group, a lower alkoxy group, a carboxyl group, an aryl group and an aralkyl group; Q is a single bond or a group of the formula --CO--O--, --O--CO--, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH--, --OCH.sub.2 --, --SCH.sub.2 --, --CH.sub.2 O-- or --CH.sub.2 S--; each of R.sup.1, R.sup.2, R.sup.3 and R.sup.4 which are the same or different, is a hydrogen atom, a halogen atom, a lower alkyl group, a hydroxyl group, a lower alkoxy group, or an aryl or heteroaromatic ring group which may have substituent(s) selected from the group consisting of a halogen atom, a lower alkyl group and a lower alkoxy group; each of R.sup.5, R.sup.6 and R.sup.7 which are the same or different, is a hydrogen atom or a lower alkyl group; and R.sup.8 is a hydrogen atom, a lower alkyl group, a lower alkenyl group, a lower alkynyl group or an aralkyl group, provided that when Q is a single bond, ##STR3## are not simultaneously 4-chlorophenyl groups.

Substituted amic acid derivatives

A compound of the formula (I) or its pharmaceutically acceptable salt or ester: ##STR1## wherein each of the substituents are herein defined.

A compound of the formula (I) or its pharmaceutically acceptable salt or ester: ##STR1## and intermediates thereof.

Substitute amic acid derivatives

The substituted alkylamine derivatives represented by formula (I) ##STR1## wherein R.sup.1 represents (a) substituted or unsubstituted C.sub.2-6 alkenyl group, (b) substituted or unsubstituted C.sub.3-6 cycloalkenyl group, (c) substituted or unsubstituted C.sub.2-6 alkynyl group, (d) substituted or unsubstituted aryl group, (e) substituted or unsubstituted heterocyclic group, (f) fused heterocyclic group which may be substituted, or (g) group represented by the formula Ru.sup.11 -Ar wherein R.sup.11 is a heterocyclic group and Ar is a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and which may be substituted; ##STR2## represents a 5- or 6-membered aromatic ring which may contain a hetero N, O or S atom, and may be substituted by R.sup.7,

Substituted alkylamine derivatives

A substituted pyridine derivative represented by the general formula ##STR1## wherein R.sup.1 represents a phenyl or naphthyl group which may optionally be substituted by a substituent selected from the class consisting of a hydroxyl group, lower alkyl groups, lower alkoxy groups, cycloalkyl groups, lower alkoxycarbonyl groups, a phenyl group and halogen atoms; X represents an oxygen atom, a sulfur atom, a carbonyl group, or a group of the formula --CH(OH)-- or --N(R.sup.a)-- in which R.sup.a is a hydrogen atom or a lower alkyl group; Y represents a linear or branched lower alkylene group or a vinylene group which may optionally be substituted by a lower alkyl group, with the proviso that when X is an oxygen or sulfur atom, Y represents the lower alkylene group; R.sup.2 and R.sup.3 are identical or different and each represents a hydrogen atom or a lower alkyl group; R.sup.4 represents a hydrogen atom, a lower alkoxy group, a cycloalkyloxy group, a lower alkylthio group, a cycloalkylthio group, an aryloxy group, an aralkyloxy groups or a group of the formula ##STR2## in which R.sup.b and R.sup.c are identical or different and each represents a hydrogen atom or a lower alkyl group. or R.sup.b and R.sup.c, taken together, may form together with the adjacent nitrogen atom a 5- to 7-membered saturated heterocyclic ring which may optionally contain at least one additional hetero atom selected from the group consisting of oxygen, sulfur and nitrogen atoms and may optionally be substituted by a lower alkyl group; m and n are each 0 or 1, with the proviso that m and n are not 0 at the same time, or an acid addition salt thereof. This compound is useful as an antiulcer agent.

Anti-ulcer substituted pyridine derivatives

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Tsukuba, Japan

Yoshiaki Iida