Teijin Limited

Teijin Pharma Limited

Yoshiaki Azuma

Norihiro Yamada

Yoshimasa Takahashi

Tsutomu Maeda

Yasunori Nakayama

Eiji Ochiai

Hitoshi Wada

Yoshifumi Harada

Kei Yamana

Tomohiro Ohta

Atsuo Hazato

Kenji Manabe

Masayasu Tabe

Osami Takenouchi

Koji Tomimori

[PROBLEMS] To provide a polypeptide having a novel structure and showing an activity of inhibiting angiogenesis or an activity of inhibiting osteoclastogenesis, and to provide a recombinant protein by constructing a method of purifying the above protein. To provide an ingredient useful in designing remedies for tendinitis, rheumatoid arthritis, arthritis deformans, malignant tumor, etc. [MEANS FOR SOLVING PROBLEMS] A novel soluble polypeptide protein.

Protein and production process and use thereof

[Problems] To provide a polypeptide having a novel structure and showing an activity of inhibiting angiogenesis or an activity of inhibiting osteoclastogenesis, and to provide a recombinant protein by constructing a method of purifying the above protein. To provide an ingredient useful in designing remedies for tendinitis, rheumatoid arthritis, arthritis deformans, malignant tumor, etc. [Means for Solving Problems] A novel soluble polypeptide protein.

A method enabling a destroyed part of a joint or joint cartilage to be extracted accurately and at a high speed with a good repeatability and enabling quantitative and simple 3D analysis of the joint and the destroyed part, that is, a method of 3D image processing comprising filling in a medullary cavity region, comprised of a hollow region inside a joint, of a digitalized image of a cross-section of the examined joint using the Expansion and Shrinkage method, performing 3D labeling by a 3D image obtained by stacking digitalized images of cross-sections of the examined joint generated at a step of extracting a contour of the cross-sectional image of the joint or digitalized images of cross-sections of the examined joint not pre-processed, and defining the joint image to be evaluated.

Three-dimensional joint structure measuring method

This invention relates to a bone measurement method for measuring a bone shape, structure and architecture on the basis of the tomographic images of a test bone or joint, in more detail, to a bone measurement method characterized by having a template image extraction step for obtaining a wholly continued template image of a bone inner portion surrounded by a cortical bone from the binary image of a test bone cross section, and separating a cortical bone and a cancellous bone by the product of said template image and said binary image, as a bone measurement method which enables the automatic, high-speed and repeatable separation of a cortical bone and a cancellous bone on the basis of the binary image of a test bone or joint cross section and by which a separated three-dimensional image of the cortical bone portion and the cancellous bone portion is obtained as the bases for a non-invasive analyses of three-dimensional bone structure, bone strength, and the like.

Bone measuring method

A lactone compound, useful as an osteogenetic accelerator, having the formula (I): ##STR1## wherein n is zero or 1 and m is zero or 1, provided that both n and m are not zero at the same time, or a stereoisomer thereof at the 23- and/or 25-positions or any mixture thereof and a production process thereof.

Lactone compound and process of production thereof

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Tokyo, Japan

Yoshiaki Azuma