Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Hadasit Medical Research Services and Development Ltd.

Aristotle University of Thessaloniki

Al-quds University

Yosefa Avraham

Elliot Berry

Yossi Dagon

Yaron Ilan

Raphael Mechoulam

Jehoshua Katzhendler

Yousef Najajreh

Meir Saidian

Iddo Magen

Raphael Mevorach

Nicholas Grigoriadis

Theofilos Poutachidis

The compounds D9-tetrahydrocannabinol (THC), cannabidiol (CBD) and capsaicin are useful for prevention, treatment, or both, of hepatic encephalopathy. The compounds capsaicin, 2-arachidonoylglycerol (2-AG), HU-308 and cannabidiol are useful for prevention, treatment, or both, of liver cirrhosis.

Treatment of hepatic encephalopathy and liver cirrhosis

Provided are new fatty acid derivatives, methods for their preparation, pharmaceutical compositions including such compounds, and methods of using these compounds and compositions, e.g., as agents for the treatment of obesity and related disorders, and for improving cognition.

Compounds and methods of treating obesity

The present invention concerns using a leptin protein, a variant fragment or mimic of a leptin protein, or an activator of the AMPK signal transduction pathway for preparing a medicament that can either be used to improve cognitive function or to treat treatment of undesirable manifestations of a nutritional stress condition and to prolong survival.

Compounds for improving nutritional status, cognition and survival

Growing community of inventors

Jerusalem, Israel

Yosefa Avraham