Cnoga Medical Ltd.

Oplus Technologies, Inc.

Cnoga Holdings Ltd.

Other

Intel Corporation

Cnoga Ltd.

Yosef Segman

Gady Yearim

Avy Strominger

Yehonatan Segman

David Solomon

An apparatus generates a pulse (or other hemodynamic) signal from an ECG signal, and displays a waveform of that signal. An ECG unit comprises electrode(s) for receiving an ECG signal waveform from live tissue and for generating a digital ECG signal; a memory storage; hardware processor(s) configured to constantly apply an integral function to the digital ECG signal and display a waveform of the integral function during a time period. The waveform of the integral function has a shape of a pulse signal waveform of the subject during the time period. The integral function comprises()(())ECG(u) represents an ECG over a specific time period using a specific time resolution. T is determined from the ECG(u) time resolution and pulse frequency, T satisfies the Nyquist sampling theory, t, u are time variables and A is a positive constant. The memory stores the integral function waveform. A weight function()(())&#xb7;()may be included.

Apparatus and method for using ECG to recover pulse waveform and other hemodynamics

Apparatus for determining height, width, weight or body mass index (BMI) of a subject or distance along an object. For BMI, the apparatus includes a digital camera; an application; a processing unit for storing the vertical and horizontal dimensions of known substantially rectangular reference objects. A user interface prompts and receives the type of reference object held by the user or its dimensions. For each of the vertical and horizontal dimensions, a magnitude in pixels and in distance of the reference object to form a ratio and a pixel magnitude of the vertical and horizontal dimensions of the subject in the image(s), is used to derive an estimated height and width of the subject from the pixel magnitude of the vertical and horizontal dimensions of the subject in the image(s). In some embodiments, the number of pixels occupied by the subject in the image(s) is used with a look-up table.

BMI, body and other object measurements from camera view display

An apparatus obtaining a pH level of a tissue comprises an array of at least three optical sensors configured to absorb light shined on the tissue and thereby obtain at least three electronic digital signals, wherein the first electronic signal A(X,t) represents the light absorbed by the tissue in location X=(X,Y,Z) at time t and at wavelength L, and similarly the second and third electronic signal A(X,t) and A(X,t), and a finite absorption range of the three wavelength L, L2 and Lis such that 0&#x3c;=A(X,t)&#x3c;=A(X,t)&#x3c;A(X,t); and an electronic processing unit receives the signals and applies an ordered monotone function, F1, to the tissue, to spatial temporal information of each wavelength, F1 used by a transfer function for presentation as a LookUp Table connecting actual values computed by F1 and an actual pH of the tissue in location X at time t.

Apparatus and method of generating pH of subject from at least three wavelengths

An apparatus for monitoring blood glucose comprising an invasive component for invasively measuring blood glucose and a non-invasive component, including color image sensor(s) to generate images from absorption of light that traversed the tissue, to receive a body part and generate a non-invasive blood glucose reading. Processor(s) convert the images into a vector V associated with a particular at least one invasive blood glucose measurement g, form a regular learning matrix, &#x3bb;, implement a noninvasive isolation mechanism of the tissue glucose level by unique association of the vector Vwith an invasive blood glucose level, determine a neural network from the learning set &#x3bb; by pairing vectors into a branch and forming multiple branches into loops, wherein two vectors are paired if they have a pre-defined similarity in the blood glucose levels that each are associated with; and calibrate the neural network by having it pass at least one test.

Method and apparatus for non-invasive glucose measurement

Device for measuring blood pressure hemodynamically in blood vessels at one or more body locations comprising light source; at least three sensors including an array of at least three optical sensors, for receiving light and for obtaining a signal over time comprising temporal per pixel information for at least two wavelengths of light, and corresponding to a flow of blood within a blood vessel over time; a processing unit configured to receive the signal and generate a continuous dynamic blood pressure reading by using the temporal per pixel information for the at least two wavelengths of light to produce heart rate signals from the blood flow, and by applying a modified Windkessel model on the signal such that the blood pressure also depends on a spatial temporal pressure resistance function over time that depends on a body location of the blood flow over time, the pressure resistance function representing elastance/stiffness.

Method and device for computing optical hemodynamic blood pressure

Apparatus for testing bioparameter monitoring devices includes artificial organs that comprise an elongated sponge wrapped in electrically conductive hydrogel skin, inlet and outlet tubes having a reddish liquid flowing therein and a pulsatile pump configured to generate a pulsatile flow of the liquid. A valve has a variable opening. For each artificial organ: the inlet tube extends out of the sponge and connects eventually to the pulsatile pump, the inlet tube penetrating the elongated sponge so as to extend to a tip of the elongated sponge at a distal end of the inlet tube, and the outlet tube extends out of the elongated sponge and connects eventually to the pulsatile pump at a proximal end of the outlet tube, the outlet tube penetrating the sponge so as to extend to a tip of the elongated sponge at a distal end of the outlet tube.

Artificial tissue apparatus for testing non-invasive bioparameter measuring devices

A space-saving structural component for a device, the device configured to non-invasively determine a tissue bioparameter of a mammalian subject, the component comprising a wall surface including a grooved recess and at least one shoulder; and a substantially flat cover, the cover configured to cover the wall surface by moving from an open position far enough away from the wall surface to allow insertion of an appendage of the subject into a chamber defined by the grooved recess and the cover, to a closed position, the cover comprising a flexible material that, in the closed position, elastically deforms away from the wall surface when the appendage is present in the grooved recess and restores to a substantially flat state when the appendage is absent from the grooved recess, wherein in the closed position, when the appendage is absent from the recess, the cover is adjacent the at least one shoulder.

Bioparameter determining device with space-saving component for appendage

A cosmetic regimen and/or a nutrition regimen is outputted almost instantly to a user who transmits a digital color image, preferably video, of the surface tissue, for example at the face of a human to a web site. The regimen is custom tailored to the surface tissue type of the subject. The surface tissue type is based on value ranges of multiple surface tissue bioparameters, such as surface tissue moisture, surface tissue collagen levels, surface tissue pH and surface tissue sun sensitivity. The system may track changes in the surface tissue parameters between one digital color image provided by a user at one time and a further digital color image provided later.

Web site providing cosmetic and nutrition regimen from color images

An apparatus for working in conjunction with a digital sensor, CPU and display of a host device in order to measure blood characteristics that includes a housing configured for association with the host device so as to define between them a chamber into which at least a portion of an appendage of a living being is placed such that a tip of the appendage is deployed adjacent to the digital sensor so as to cover the digital sensor. The chamber substantially encloses the digital sensor. Light from a light source is directed toward the appendage tip, wherein at least some light from the light source is reflected by tissue of the appendage, is received by the sensor and data thereby generated is processed by the CUP to determine the blood characteristics.

Apparatus for measuring blood characteristics for deployment on a host device having a digital sensor

In a combination invasive and non-invasive bioparameter monitoring device an invasive component measures the bioparameter and transmits the reading to the non-invasive component. The non-invasive component generates a bioparametric reading upon insertion by the patient of a body part. A digital processor processes a series over time of digital color images of the body part and represents the digital images as a signal over time that is converted to a learning vector using mathematical functions. A learning matrix is created. A coefficient of learning vector is deduced. From a new vector from non-invasive measurements, a new matrix of same size and structure is created. Using the coefficient of learning vector, a recognition matrix may be tested to measure the bioparameter non-invasively. The learning matrix may be expanded and kept regular. After a device is calibrated to the individual patient, universal calibration can be generated from sending data over the Internet.

Combination non-invasive and invasive bioparameter measuring device

Optical sensor devices, image processing devices, methods and computer readable code computer-readable storage media for detecting biophysical parameters, chemical concentrations, chemical saturations, vital signs and physiological information such as a malignant condition are provided. In some embodiments, the optical sensor includes an array of photodetectors, where each photodetector is configured to detect a spectrum of light. In some embodiments, the image processing device receives a live still or video electronic image, or alternatively, the electronic image is provided from an electronic storage media. Exemplary physiological parameters include but are not limited to a pulse rate, a biophysical or physiological property of skin, a cardiovascular property, a property related to an organ such as the liver or the kidneys, and a temperature fluctuation. In some embodiments, the physiological parameter is indicative of a malady including but not limited to an autoimmune disease, a cancer, a nutritional deficiency, a malignant condition of bone marrow, a present of an infectious microbe such as a fungus, a present of hepatitis, and a cardiovascular disorder a pulmonary disorder. Exemplary chemical concentrations include but are not limited to a chemical saturation, a pH level, a pH level in blood vessels such as capillaries or in skin, a glucose level such as a blood glucose level, a urea nitrogen level such as a blood urea nitrogen level, a CO2 level such as a blood CO2 level or a CO2 saturation level, and an oxygen level such as a blood oxygen level or a blood oxygen saturation level. In some embodiments, the biophysical parameter, physiological parameter or chemical concentration is obtained from reflecting light from tissue from a mammalian subject. Alternatively one or more of these parameters are detected from a food item such as food tissue, a consumable beverage such as an alcoholic beverage, a dairy product, wine, a baked good, a fruit and a vegetable. Exemplary parameters related to food items include but are not limited to a parameter indicative of cooking or spoilage, a pH, a concentration of an antioxidant, and a concentration of an anti-inflammatory agent.

Optical sensor device and image processing unit for measuring chemical concentrations, chemical saturations and biophysical parameters

Optical sensor devices, image processing devices, methods and computer readable code computer-readable storage media for detecting biophysical parameters, chemical concentrations, chemical saturations and blood count. In some embodiments, the image processing device receives a live still or video electronic image. Exemplary physiological parameters include but are not limited to a pulse rate, blood pressure, glucose, stroke volume of internal or external tissue (e.g. skin). A biophysical or physiological property is not limited to a cardiovascular or liver or the kidneys or to a cardiovascular disorder or to a pulmonary disorder. Exemplary chemical concentrations or saturation includes but not limited to a pH level, a glucose level, a urea nitrogen level, a CO2 concentration or saturation, or a oxygen concentration or saturation. In some embodiments the parameters are detected from a food or a beverage such as an alcohol, a dairy product, wine, a baked good, a fruit or a vegetable.

Finger mounted non-invasive device for measuring physiological parameters

The present invention relates to a device for measuring blood and physiological characteristics by passing light through human tissue that is configured for deployment on a human finger. The device includes a lower finger-trough configured in the main housing of the device; a hingedly attached closeable lid that has an upper finger-trough configured for deployment of at least one finger stabilizing element, the lid being latchable in a closed position; a finger stabilizing element made of a material having flexibly soft malleable characteristics so as to sealingly engage the top of the finger; a light source that is deployed in the sloped end wall of the lower finger-trough adjacent to the lower portion of the finger tip; and an end cap the is deployable on the open end of the device when the lid is in the closed position, which enables calibration of the device with a minimum of light wave 'noise' from ambient light.

Growing community of inventors

Zichron Yaacov, Israel

Yosef Segman