Earlysense Ltd.

Edwards Lifesciences Innovation (israel) Ltd.

Visioncare, Inc.

Valtech Cardio Ltd.

G.i. View Ltd.

Ams Research Corporation

Astora Women's Health, LLC

Nano-retina, Inc.

Beta-o2 Technologies Ltd.

Visioncare Ophthalmic Technologies Inc.

Prostaplant Ltd.

Yosef Gross

Oz Cabiri

Avner Halperin

Amir Gross

Daniel H Lange

Isaac Lipshitz

Itzhak Pinhas

Tal Reich

Eran Miller

Yuval Zipory

Eli Aharoni

Gideon Dotan

Tal Hammer

Tal Sheps

Yoseph Weitzman

Ross A Longhini

Yaron Herman

Ra'anan Gefen

Boris Degtiar

Benad Goldwasser

Shai Vaingast

Eran Shor

Arkadi Averboukh

Uriel Aba Pomerantz

Pnina Vardi

Aram Ayvazian

Konstantin Bloch

Francesco Maisano

Daria Bloch

Nizza Boukobza

Dotan Gedeon

Apparatus is provided for repairing a cardiac valve, the apparatus including a catheter sized for delivery through vasculature of a subject and an elongated and flexible annuloplasty structure having an annuloplasty structure axis. The annuloplasty structure is sized and configured for delivery to a heart of the subject through the catheter substantially along a catheter axis of the catheter while the annuloplasty structure axis is substantially parallel to the catheter axis. The apparatus also includes a plurality of anchors configured for delivery to a region of cardiac tissue from a proximal end of the catheter toward a distal end of the catheter and substantially along the annuloplasty structure axis and the catheter axis while at least a portion of the annuloplasty structure is within a delivery passage of the catheter. Other embodiments are also described.

Annuloplasty ring delivery catheters

An implantable prosthetic device for repairing a native valve includes a first clip, a second clip, a first cord, and a second cord. The first clip has a first arm and a second arm and is moveable between an open position and a closed position. The second clip has a third arm and a fourth arm and is moveable between an open position and a closed position. The first cord is operatively coupled to the first clip for moving the first clip between the open and closed position. The second cord is operatively coupled to the second clip for moving the second clip between the open and closed position. The device is configured to clamp a first leaflet of the native mitral valve between the first arm and the second arm and to clamp a second leaflet of the native mitral valve between the third arm and the fourth arm.

Method and apparatus for repairing a heart valve

A first part of an annuloplasty structure is anchored to an annulus of a valve of a heart by using a driver to screw a tissue-coupling element of a first anchor into a first site of the annulus, such that the tissue-coupling element enters cardiac tissue in a direction parallel to a central longitudinal axis of the driver through the distal end of the anchor driver. The same is subsequently done for second and third parts of the annuloplasty structure using second and third anchors at second and third sites of the annulus,. Between anchors, the driver is retracted out of the heart. Subsequently, the valve is treated by reducing a distance between the first site and the second site, and a distance between the second site and the third site, by tightening a flexible and elongate contracting member of the annuloplasty structure.

Deployment techniques for annuloplasty structure

Systems and apparatuses herein include a longitudinal member having opposite first and second end portions, a tension of the longitudinal member being adjustable to repair an atrioventricular valve of the patient. A delivery tool can be configured to couple the first end portion of the longitudinal member to a first portion of heart tissue, couple the second end portion of the longitudinal member to the leaflet, adjust tension of the longitudinal member, assume a first diameter at a portion of the delivery tool that passes between the leaflets of the atrioventricular valve, during coupling of the first end portion of the longitudinal member to the first portion of heart tissue, and assume a second diameter that is smaller than the first diameter, at the portion of the delivery tool that passes between the leaflets of the atrioventricular valve, during adjusting of the tension of the longitudinal member.

Implantation of repair chords in the heart

Apparatus is provided, including an implant including a tissue-adjusting member including a longitudinal member, and a tissue anchor coupled to the tissue-adjusting member and configured to be anchored into the tissue of the patient. A tissue-coupling element is coupled to the longitudinal member. A delivery tool is reversibly couplable to the implant and is configured to deliver the implant to the tissue of the patient. The delivery tool includes an elongate shaft, a tissue-coupling-element holder coupled to a portion of the elongate shaft, the tissue-coupling-element holder being configured to hold the tissue-coupling element during delivery of the implant to the tissue of the patient, and an actuating element configured to rotate the tissue anchor so as to facilitate anchoring of the tissue anchor into the tissue of the patient while not rotating the tissue-coupling-element holder with respect to the shaft.

Systems and methods for tissue adjustment

A method is provided, including treating a heart valve of a patient by implanting at the heart valve an implant including an elongate element including at least in part a tension element, by placing the implant at the heart valve of the patient, and subsequently to the placing, increasing tension of the elongate element at least in part. The tension element is configured to undergo conformational changes, subsequently to the placing, responsively to a cardiac cycle of the patient. Implanting the implant includes implanting the implant such that the tension element undergoes the conformational changes responsively to the cardiac cycle of the patient in a manner in which the tension element cyclically increases and decreases pressure applied to at least one leaflet of the heart valve by the elongate element.

Mitral valve treatment techniques

A method is described for use at a valve of a heart of a subject, the valve having an annulus, and the heart having an atrium upstream of the valve. A distal end of a manipulator is transluminally advanced into the atrium. A first part of an implant that includes an elongated contracting member is anchored to a first site on the annulus using the manipulator. The distal end of the manipulator is then pointed at a second site on the annulus such that a central longitudinal axis of the manipulator is disposed at an angle of 45-90 degrees with respect to a surface of the annulus. A second part of the implant is then anchored to the second site using the manipulator. Subsequently, the first site and the second site are drawn together by applying tension to the contracting member. Other embodiments are also described.

Deployment techniques for annuloplasty implants

Apparatus is provided for repairing a cardiac valve, the apparatus including a catheter sized for delivery through vasculature of a subject and an elongated and flexible annuloplasty structure having an elongated lumen and an annuloplasty structure axis extending along the lumen. The annuloplasty structure is sized and configured for delivery to a heart of the subject through the catheter substantially along a catheter axis of the catheter while the annuloplasty structure axis is substantially parallel to the catheter axis. The apparatus also includes a plurality of anchors configured for delivery to a region of cardiac tissue from a proximal end of the catheter toward a distal end of the catheter and substantially along the annuloplasty structure axis and the catheter axis while at least a portion of the annuloplasty structure is within a delivery passage of the catheter. Other embodiments are also described.

Apparatus is provided, including an implantable mechanical support comprising a mesh shaped to support a portion of a urethra of a patient. One or more electrodes, coupled to the mesh, so as to contact tissue of the patient when the mechanical support () is implanted in the patient. A control unit drives the electrodes to apply a current to the tissue. Other embodiments are also described.

Electrode sling for treating stress and urge incontinence

Apparatus for monitoring a subject is described. A sensor monitors the subject during a sleeping session of the subject, and generates a sensor signal in response thereto. A control unit analyzes the sensor signal. In response to analyzing the sensor signal, the control unit performs an action selected from the group consisting of: identifying that the subject is currently undergoing an apnea episode, and predicting that the subject is going to undergo an apnea episode. In response thereto, the control unit changes a position of at least a portion of a body of the subject by activating a device. Other applications are also described.

Monitoring a condition of a subject

Apparatus and methods are described, including apparatus for predicting an onset of a clinical episode. The apparatus includes a sensor, configured to sense at least one parameter of a subject substantially continuously during a period having a duration of at least one hour, and a control unit, configured to predict, at least one hour prior to the onset of the clinical episode, the onset at least in part responsively to the sensed parameter. Other applications are also described.

Prediction and monitoring of clinical episodes

Apparatus and methods are described, included a method for detecting uterine contractions in a pregnant woman. The method includes sensing motion of the woman without contacting the woman, generating a signal corresponding to the sensed motion, and analyzing the signal to detect presence of labor contractions. Other applications are also described.

Apparatus and methods are described, including a method for treating a clinical episode. The method comprises sensing at least one parameter of a subject without contacting or viewing the subject or clothes the subject is wearing, analyzing the parameter, detecting the clinical episode at least in part responsively to the analysis, and responsively to detecting the clinical episode, treating the clinical episode using a device implanted in the subject. Other applications are also described.

A method is provided for predicting an onset of a clinical episode, the method including sensing breathing of a subject, determining at least one breathing pattern of the subject responsively to the sensed breathing, comparing the breathing pattern with a baseline breathing pattern, and predicting the onset of the episode at least in part responsively to the comparison. Other embodiments are also described.

Techniques for prediction and monitoring of coughing-manifested clinical episodes

Apparatus for use with an external non-visible light source is provided. The apparatus comprises an intraocular device configured for implantation in a human eye, and comprising an energy receiver. The energy receiver is configured to receive light emitted from the external non-visible light source, and extract energy from the emitted light for powering the intraocular device. The intraocular device is configured to regulate a parameter of operation of the intraocular device based on a modulation of the light emitted by the external non-visible light source and received by the energy receiver. Other embodiments are also described.

Growing community of inventors

Moshav Mazor, Israel

Yosef Gross