Nippon Chemiphar Co., Ltd.

Yoriko Shinohara

Tadashi Kobayashi

Tomio Yamakawa

Shinichi Yoshida

Kunio Kobayashi

Nobutaka Mochiduki

Atsushi Tendo

The invention relates to compounds of the following formula (I) or their salts: in which Ris a group of phenyl, naphthyl, pyridyl or the like which may have a substituent such as an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, an alkoxycarbonyl group having 2-8 carbon atoms, carboxyl, halogen, hydroxyl, nitro, or cyano; Ris cyano, nitro, or the like; Ris hydroxyl or the like; X is oxygen, sulfur, or the like; and Y is oxygen or sulfur, and a xanthine oxidase inhibitor containing the compound.

Substituted 1,3-thiazolo[5,4-d]pyrimidines as xanthine oxidase inhibitors

The invention relates to compounds of the following formula (I) or their salts: in which Rrepresents ORor others, in which Ris an alkyl group having 1-8 carbon atoms which may have a substituent or the like; Ris halogen, nitro, cyano, carboxyl, or the like; Ris hydrogen, halogen, hydroxyl, amino, carboxyl, or the like; X is NR, oxygen, or sulfur, in which Ris hydrogen, or an alkyl group having 1-8 carbon atom which may have a substituent; and each of Y and Z is CRor nitrogen, in which Rhas the same meaning as Rabove, and a xanthine oxidase inhibitor containing the compound as an active ingredient.

Substituted thiazolopyrimidines as xanthine oxidase inhibitors

Growing community of inventors

Chiba, Japan

Yoriko Shinohara