University System of Maryland

Other

The United States of America, as Represented by the Secretary, Department of Health and Human Services

Yordan Kostov

Govind Rao

Leah Tolosa

Xudong Ge

Douglas D Frey

Mustafa Al-Adhami

Chandrasekhar Gurramkonda

Hung Lam

Michael Tolosa

Benjamin Punshon-Smith

Rajani Adiga

David Burgenson

Sevda Deldari

Abhay Andar

Steven Mitchell Falk

Hugh Alan Bruck

Rose Viscardi

Shayan Gholipour Borhani

Minghui Yang

Hyung Woo

Kevin Tran

Monohar Pilli

Virendra Singh

Lam Hung

Leah Tolosa Croucher

Avraham Rasooly

Chandrashekar Gurramkonda

Vikash Kumar

Vida Rahmatnejad

Manohar Pilli

Hugh A Bruck

The present invention relates to cell free protein manufacturing, and more particularly, for integrating machine learning into a portable cell-free bioprocessing system for producing proteins with increased and consistent purity, potency and quality wherein such proteins are prepared on-demand and for point-of-care delivery.

Methods to incorporate machine learning analytics for optimizing protein purity, potency and quality in an on-demand production system for point-of-care delivery

A device and method for detecting the presence of bacteria in a sample are provided. A multi-step process for sample preparation is utilized and a microfluidic device is disclosed. The detection is performed using microfluidics and physical changes in multiple samples in differential mode.

Method and apparatus for rapid detection of bacterial contamination

The present invention provides for a fully integrated microfluidic system capable of producing single-dose amounts of biotherapeutics at the point-of-care wherein protein production, purification and product harvest are all integrated as a single microfluidic device which is portable and capable of continuous-flow production of biotherapeutics at the microscale using a cell-free reaction system.

Factory-on-a-chip for production of biologically derived medicines/biopharmaceuticals/biologics/biotherapeutics

A bioprocessing system for protein manufacturing from human blood is provided that is compact, integrated and suited for on-demand production and delivery of therapeutic proteins to patients. The parent's own blood can be used as the source of cell extracts for the production of the therapeutic proteins.

Microscale bioprocessing system and method for protein manufacturing from human blood

A portable and mobile bioprocessing system and method for protein manufacturing that is compact, integrated and suited for on-demand production of any type of proteins and for delivery of the produced proteins to patients or for assay purposes. The portable system and method can also be used for efficient on-demand production of any type of protein with point-of-care delivery.

System and method for production of on-demand proteins in a portable unit for point of care delivery

Systems and methods for determining an in vivo concentration of a small molecule substance of interest is provided that takes advantage of the semi-permeable nature of skin, which allows small molecules to passively diffuse through the skin and onto the skin surface. The systems and methods of the present invention allow for the collection of these small molecules that have passively diffused through the skin without skin disruption or breaking of the skin. The systems and methods of the present invention are noninvasive, painless and safe even for delicate newborns, and are particularly suited for the determination of blood glucose in newborns and infants in a noninvasive manner.

System and method for determining an in vivo concentration of a small molecule substance of interest in a noninvasive manner

A noninvasive remote parameter sensor and sensing method is provided that is particularly suited for the remote monitoring of skin temperature. The sensor and sensing method utilize luminescence-based sensors that are non-toxic and non-irritating to the skin. The sensor preferably utilizes one or more types of fluorophores that are embedded in a soft hydrogel. The sensor is illuminated with excitation light, and temperature is monitored by detecting and analyzing the emission light from the fluorophores. Because a soft hydrogel is used, the sensor can be gently wiped off the skin at the conclusion of temperature measurements.

Luminescence based noninvasive remote parameter sensor and sensing method

Growing community of inventors

Columbia, MD, United States of America

Yordan Kostov