Codexis, Inc.

Yoram Barak

Fernando Valle

Jonathan Vroom

Louis Clark

Kristian Karlshoej

Kaman Chan

Svetlana Balatskaya

Jovana Nazor

Claus M Krebber

Catherine M Cho

Kenneth W Mitchell

Patricia Choudhary

Trish Choudhary

The invention generally relates to the production of a fatty alcohol composition from recombinant microbial cells. The fatty alcohols are produced by expressing a gene encoding a heterologous fatty alcohol forming acyl-CoA reductase ('FAR'); a gene encoding a heterologous thioesterase ('TE') gene and a gene encoding an acyl-CoA synthetase (&#x201c;ACS&#x201d;).

Production of fatty alcohols from engineered microorganisms

Recombinant microorganisms are provided which have been engineered to produce fatty alcohols. Also provided are recombinant microorganisms which comprise a heterologous polynucleotide encoding a fatty alcohol reductase enzyme and an introduced polynucleotide encoding a &#x3b2;-ketoacyl acyl carrier protein synthase.

Recombinant bacterial microorganisms are provided which comprise heterologous fatty acyl reductases ('FAR') polypeptides wherein said microorganisms have been engineered to produce increased amounts of saturated fatty alcohols and methods of making saturated fatty alcohols using the recombinant bacterial microorganisms.

Production of saturated fatty alcohols from engineered microorganisms

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Greenwich, CT, United States of America

Yoram Barak