Industry-academic Cooperation Foundation, Chosun University

Chosun University

Board of Trustees of the University of Arkansas

Yoonkyung Park

Kyung-Soo Hahm

Jong-Kook Lee

Hyeonsook Cheong

Cheryl Armstrong

Hee Kyoung Kang

Kyung-soo Hahm

Seong-Cheol Park

Peter I Song

Eunji Park

Dong Gun Lee

Min-Kyung Kim

Hyomi Han

Sunhyo Ryu

An antimicrobial peptide according to an embodiment of the present disclosure has the amino acid sequence of SEQ ID NO: 1, wherein i) the 1st and the 20th to the 24th amino acids are deleted, ii) the 1st and the 20th to the 24th amino acids are deleted and the 11th or the 18th amino acid is substituted with lysine (K), or iii) the 1st and the 20th to the 24th amino acids are deleted and the 11th and the 18th amino acids are substituted with lysine (K).

Antimicrobial peptide derived from Pseudin-2 peptide and uses thereof

A novel antimicrobial peptide derived from LL37 peptide has not only an excellent antimicrobial activity for Gram-positive bacteria, Gram-negative bacteria, and antibiotic tolerant bacteria but also low cytotoxicity for cells derived from mouse or human. It can be advantageously used as an effective component of antimicrobial antibiotics, cosmetic composition, food additive, animal feed additive, biopesticides, and quasi-drug.

Antimicrobial peptide derived from LL37 peptide and uses thereof

An antimicrobial peptide has the amino acid sequence of SEQ ID NO: 1, except that i) the 1st and the 14th amino acids are deleted, ii) the 4th and the 8th amino acids are substituted with lysine (K), iii) the 7th amino acid is substituted with leucine (L), iv) the 9th amino acid is optionally substituted with lysine (K), and v) the 12th amino acid is optionally substituted with lysine (K). A method for antimicrobial treatment in a subject including administering a pharmaceutically effective amount of the antimicrobial peptide to a subject.

Antimicrobial peptide derived from Hp1404 peptide and uses thereof

A method for treating a microorganism or inflammation caused by the microorganism includes administering or applying a composition comprising an antimicrobial peptide with the amino acid sequence of SEQ ID NO: 1 to a subject in need thereof. Because the antimicrobial peptide with the amino acid sequence of SEQ ID NO: 1 exhibits an excellent antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria and also low cytotoxicity for human erythrocytes, it can be advantageously used for various applications.

Antimicrobial peptide from skate skin and uses thereof

A novel antimicrobial peptide is derived from myxinidin peptide. The novel antimicrobial peptides (i.e., myxinidin 2 and myxinidin 3) have low cytotoxicity for human cells while exhibiting an excellent antimicrobial activity, and exhibit an anti-inflammatory and a wound healing effect. Thus, they can be advantageously used as an effective ingredient of antibiotics, a cosmetic composition, a food additive, an animal feed additive, biopesticides, and a quasi-drug product or the like.

Antimicrobial peptide derived from myxinidin peptide and uses thereof

The present invention relates to a novel analogue antibiotic peptide derived from a CM-MA peptide and a use thereof. Specifically, the novel antibiotic peptides represented by SEQ. ID. NO: 2 to SEQ. ID. NO: 7 (CAM 1 to CMA 6) were synthesized by using a CM-MA antibiotic peptide, in which amphiphilic cecropin A (CA) and magainin 2 (MA) are conjugated, as a template. The synthesized antibiotic peptide exhibits antibiotic activity on gram-positive bacteria and gram-negative bacteria and low cytotoxicity on human red blood cells and human normal cell lines (HaCaT), and thus the antibiotic peptide of the present invention can be favorably used as an active ingredient of an antibiotic agent, a cosmetic composition, a food additive, a feed additive, and a biological pesticide.

Analogue peptide CMA3 derived from CM-MA peptide and use thereof

The present invention encompasses methods for treating an infection and/or treating or reducing inflammation through the administration of a therapeutically effective amount of a peptide to a subject in need thereof. In some aspects, the peptide is a-derived peptide, such as an HPA3NT3 peptide and the infection is a bacterial infection.

Methods of use for an antimicrobial peptide

The present invention relates to a new antibiotic peptide and a usage thereof, which are derived from ribosomal protein L1, RPL1 of. Specifically, the antibiotic peptide comprising the amino acid sequence of SEQ. ID. NO:1 derived from ribosomal protein L1, RPL1 ofis substituted with a Phenylalanine, which is situated at the first and the eighth position from the antibiotic peptide, or in addition an Asparagine, which is situated at the thirteenth position of the antibiotic peptide, is substituted with lysine, wherein the produced peptides have maintained more decreased cytotoxicity when comparing to the existing antibiotic peptides and can be used as a safe antibiotics by showing more antibacterial activity.

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The present invention relates to novel peptides with increased &plus; charge and hydrophobicity by substituting one or more amino acids of CA-MA peptide in which cecropin A (CA) and magainin 2(MA) were conjugated and pharmaceutical compositions containing thereof. More precisely, the present invention relates to synthetic peptides prepared by substituting one or more amino acids of CA-MA peptide represented by the SEQ. ID. NO: 1 with amino acids having &plus; charge and hydrophobicity and anti-bacterial, anti-fungal and anticancer compositions containing thereof. The synthetic peptides of the present invention have no cytotoxicity but have excellent anti-bacterial, anti-fungal and anticancer activity, leading in an effective use thereof as a safe anticancer agent and antibiotics.

Peptides with increased &plus; charge and hydrophobicity by substituting one or more amino acids of CA-MA peptide and pharmaceutical compositions containing thereof

Growing community of inventors

Jeollanam-do, South Korea

Yoonkyung Park