Korea Research Institute of Bioscience and Biotechnology

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Institut National De La Sante Et De La Recherche Medicale

National Cancer Center

Yoonkyung Kim

Hye-Youn Jung

Kenneth Alan Jacobson

Bong Hyun Chung

Se Hun Kang

Seok Ki Kim

Christian Gachet

June-Key Chung

Ju Young Heo

Young-Hwa Kim

Dong-Eog Kim

Athena Klutz

Beatrice Hechler

Yun Hui Choe

Disclosed herein is a method of improving tumor diagnostic efficiency of multivalent ligands by regulating the stoichiometric ratio between inner surface functionalities and ligand moieties for tumor targeting, and the multivalent ligands for tumor diagnosis.

Method to improve the tumor diagnostic efficiency of multivalent ligands by regulating the stoichiometric ratio between inner surface functionalities and ligand moieties for tumor targeting

Disclosed herein is an iodine-containing radial-shaped macromolecule suitable for an active ingredient of the computed tomography (CT) contrast medium, a method to prepare the same, and a contrast medium composition including the same. With respect to the iodine-containing radial-shaped macromolecule according to the present invention, the duration of contrast enhancement has been significantly improved in comparison to that of the current small molecular contrast media compounds containing iodine.

Iodine-containing radial-shaped macromolecular compounds, preparation method thereof and contrast media compositions for CT comprising the same

The present invention relates to a reversible fluorescence photoswitch based on the dye-crosslinked dendritic nanoclusters for high-contrast imaging of living biological systems. The dendritic nanocluster according to the present invention consists of two or more dendrimers crosslinked each other to have a globular shape overall, and thereby enhancing the fluorescence intensity and improving the detection sensitivity of the monomeric dendrimers. In addition, the dendritic nanocluster according to the present invention was found to internalize into a living zebrafish by both skin permeation and microinjection, independently. Further, the dendritic nanocluster according to the present invention showed low toxicity and thus it could be useful for both in vivo and in vitro imaging as well as the ex vivo cell tracking applications.

Reversible fluorescence photoswitch based on dye-crosslinked dendritic nanoclusters for high-contrast imaging of living biological systems

Disclosed are conjugates comprising a dendrimer and a ligand, which is a functionalized congener of an agonist or antagonist of a receptor of the G-protein coupled receptor (GPCR) superfamily, for example, wherein the functionalized congener is an Aadenosine receptor agonist having a purine nucleoside moiety and a functional group at the Nposition of the purine nucleoside moiety, wherein the functional group has the formula (I): NH&#x2014;Ar&#x2014;CH&#x2014;C(&#x2550;O)NH&#x2014;R(I), wherein Arand Ras defined herein. Also disclosed are pharmaceutical compositions, methods of treating various diseases, and a diagnostic method employing such conjugates.

Dendrimer conjugates of agonists and antagonists of the GPCR superfamily

Growing community of inventors

Seoul, South Korea

Yoonkyung Kim