Medipost Co., Ltd

Other

Samsung Life Public Welfare Foundation

Curonix Co., Ltd.

Yoon-Sun Yang

Won Il Oh

Jong Wook Chang

Hong Bae Jeon

Mi Yeon Lee

Sun Jae Kwon

Soo Jin Choi

Wonil Oh

Sang Young Jeong

Mee Hyun Jung

Ju-Yeon Kim

Ji Hyun Kim

Won Soon Park

Yun Sil Chang

Soon-Jae Kwon

Miyeon Kim

Hye Jin Jin

Dal-Soo Kim

Dal Soo Kim

Ju Yeon Kim

Sung-Eun Yang

Chul-Won Ha

Won Ii Oh

Soon-jae Kwon

Disclosed is a method for culturing mesenchymal stem cells, comprising culturing mesenchymal stem cells in a medium containing calcium in a concentration of from 2.1 to 3.8 mM and magnesium in a concentration of from 1.0 to 3.0 mM under a hypoxic condition of 2 to 5% oxygen. The culturing method can increase the population of mesenchymal stem cells even with a small number of passages by improving mesenchymal stem cells in proliferative capacity and viability. In addition, the mesenchymal stem cells prepared by the culturing method are effectively used to treat or improve a pulmonary disease.

Method for culturing mesenchymal stem cells

Disclosed is a method for culturing mesenchymal stem cells, comprising culturing mesenchymal stem cells in a medium containing calcium in a concentration of from 2.1 to 3.8 mM and magnesium in a concentration of from 1.0 to 3.0 mM under a hypoxic condition of 2 to 5% oxygen. The culturing method can increase the population of mesenchymal stem cells even with a small number of passages by improving mesenchymal stem cells in proliferative capacity and viability. In addition, the mesenchymal stem cells prepared by the culturing method are effectively used not only as a safe cell therapeutic agent due to their lacking immunogenicity, but also as a cartilage regenerating medicine owing to their excellent secretion of cytokines.

Provided are a pharmaceutical composition for prevention and treatment of a neural disease including at least one selected from the group consisting of mesenchymal stem cells (MSCs), a culture solution of the MSCs, activin A, PF4, decorin, galectin 3, GDF15, glypican 3, MFRP, ICAM5, IGFBP7, PDGF-AA, SPARCL1, thrombospondin-1, WISP1, progranulin, IL-4, a factor inducing expression thereof, and any combination thereof, and a method therefor.

Composition comprising a culture solution of mesenchymal stem cells for the treatment of neural diseases

A method for culturing mesenchymal stem cells. The method includes isolating mesenchymal stem cells having a size of 8 &#x3bc;m or less and culturing the mesenchymal stem cells in a medium containing calcium and magnesium and under a low oxygen condition. The method can significantly improve the proliferative capacity and differentiation potential of the mesenchymal stem cells.

Method for culturing mesenchymal stem cells according to cell size

There is provided a method of treating lung diseases including administering cells separated or proliferated from umbilical cord blood to a patient suffering from such diseases.

Method of treating lung diseases using cells separated or proliferated from umbilical cord blood

A use of a composition comprising umbilical cord blood-derived mesenchymal stem cells for inducing differentiation and proliferation of neural precursor cells or neural stem cells to neural cells is provided, the composition being effective for the treatment of nerve injury diseases.

Administering umbilical cord blood-derived mesenchymal stem cells to treat nerve injury

Thrombospondin 1 (TSP-1), TSP-2, interleukin 17B receptor (IL-17BR) and heparin-binding epidermal growth factor-like growth factor (HB-EGF) associated with stem cell activity and use thereof.

Treating cartilage defect with UCB-MSC expressing TSP-2

Neural cell proliferation induced through the culture of neural cells with umbilical cord blood-derived mesenchymal stem cells

Method of selecting stem cells having high chondrogenic differentiation capability

The present invention relates to a pharmaceutical composition for the prevention or treatment of neurological disorders, comprising an ICAM-1 (intercellular adhesion molecule-1) protein, or a fragment or a variant thereof as an active ingredient, which can increase the expression of neprilysin to remove amyloid-beta (A&#x3b2;), a cause of dementia, and is thus useful in preventing or treating a neurological disease including Alzheimer's disease.

Use of ICAM-1 for prevention or treatment of neurological diseases

Provided is a gene therapy composition for transferring one of a therapeutic gene, a maker gene, or a mixture thereof to a cell that expresses interleukin-8 (IL-8) or GRO-&#x3b1; and induces tropism of mesenchymal stem cells isolated from umbilical cord blood and/or the mesenchymal stem cells expanded from said mesenchymal stem cells (UCB-MSCs), wherein the cell-treating composition includes UCB-MSCs. Provided is a composition for treating disease related to a cell expressing IL-8 or GRO-&#x3b1;, that is, a brain tumor in gene therapy, by using UCB-MSCs. Provided is a composition or kit for diagnosing brain tumors, preventing brain tumors, treating brain tumors, or monitoring brain tumor treatment progression by using UCB-MSCs.

UCB-MSCs comprising a tumor suppressor gene reduce the size of an IL-8 or GRO-&#x3b1;expressing tumor

The present invention relates to a novel p53 target gene SISP-1 (Stress induced Secreted Protein 1) and a SISP-1 protein encoded by the gene. The SISP-1 protein of the present invention induces apoptosis by interaction with p53. The present invention provides the use of the gene/protein associated with treating abnormal apoptosis such as tumor.

SISP-1, a novel p53 target gene and use thereof

Disclosed herein is a composition for the treatment of articular cartilage damage or loss or defect. The composition for the treatment of articular cartilage injury of the present invention includes (i) cellular components separated, proliferated, and/or differentiated from the umbilical cord blood, (ii) a culture medium; and (iii) a biocompatible polymer. The composition has very superior ability of proliferation and differentiation and easier to be collected and acquired.

Growing community of inventors

Seoul, South Korea

Yoon-Sun Yang