Seoul National University

Korea University Research and Business Foundation

Ewha University-Industry Collaboration Foundation

Chungbuk National University Industry-Academic Cooperation Foundation

Nano Intelligent Biomedical Engineering Corporation Co. Ltd.

Nibec Co., Ltd.

Yoon Shin Park

Chong-Pyoung Chung

Jue-Yeon Lee

Yoon Jeong Park

Sang Hoon Lee

Han Su Kim

Jin Sook Suh

Ji-Young Hwang

Sung Chul Jung

Ha Yeong Kim

In Ho Jo

Yesl Jun

Yoon Mi Jin

Inho Jo

Gyung Ah Kim

The present invention relates to a GRP78-derived peptide for screening highly efficient stem cells and the use thereof, and more particularly, to screening highly efficient stem cells using, as a marker, a GRP78-derived peptide capable of binding to the binding domain of GRP78 protein on the cell surface. According to the present invention, the GRP78-derived peptide comprising only a specific amino acid sequence capable of recognizing highly efficient stem cells, among the amino acid sequence of GRP78, makes it possible to screen only non-senescent young stem cells. In addition, when stem cells are treated with the GRP78-derived peptide or the GRP78-derived peptide is introduced into stem cells, the efficiency of the stem cells can be increased. Thus, the GRP78-derived peptide is useful for the production of stem cell therapy products having excellent efficacy.

GRP78-derived peptide for identifying high-efficiency stem cells

The present invention relates to a method for producing a spheroid form of tonsil-derived stem cells, the method enhances growth and differentiation efficiency of the tonsil-derived stem cells. The present method also produces a spheroid form of para-thyroid hormones. The method for producing a spheroid form of tonsil-derived stem cells enhances the proliferation rate of the stem cells per se and significantly increase differentiation potency into parathyroid cells.

Method for culturing differentiation-promoting and -sustaining spheroid form of tonsil-derived stem cells

The disclosure relates to a fat accumulation inhibitory peptide which essentially comprises an amino acid sequence represented by SEQ ID NO: 1, a pharmaceutical composition for preventing or treating obesity, which contains the peptide, and a health functional food for preventing or alleviating obesity, which contains the peptide. The fat accumulation inhibitory peptide according to the present invention has the function of inhibiting the differentiation of mesenchymal stem cells into adipocytes to thereby inhibit the accumulation of adipose tissue. Thus, the peptide according to the present invention is highly useful for the prevention or treatment of obesity.

Fat accumulation inhibitory peptide and pharmaceutical composition for preventing or treating obesity containing the same

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Seoul, South Korea

Yoon Shin Park