Pfizer Corporation

Yoon Park

Barbra Johnson Sasu

Roman Galetto

Thomas John Van Blarcom

Tao Sai

Siler Panowski

Mathilde Brunnhilde Dusseaux

Surabhi Srivatsa Srinivasan

Niranjana Aditi Nagarajan

The disclosure provides CARs (CARs) that specifically bind to CD70. The disclosure further relates to engineered immune cells comprising such CARs, CAR-encoding nucleic acids, and methods of making such CARs, engineered immune cells, and nucleic acids. The disclosure further relates to therapeutic methods for use of these CARs and engineered immune cells comprising these CARs for the treatment of a condition associated with malignant cells expressing CD70 (e.g., cancer).

Chimeric antigen receptors targeting CD70

Growing community of inventors

Seoul, South Korea

Yoon Park