Sk Chemicals Co., Ltd.

Tiumbio Co., Ltd.

Ewha University-Industry Collaboration Foundation

Yoon-Jung Lee

Nam Ho Kim

Shin Hyoung Kim

Ji-Hye Lee

Jin Young Lee

Hyun Jung Lee

Ju Young Lee

Bo Ram Lee

Jae-Sun Kim

Bong-Yong Lee

Hun-Taek Kim

Keun Ryu

Kyu Ho Lee

Sung Hoon Park

Nam Kyu Lee

Je Ho Ryu

Hoe Chul Jung

Jung A Lee

Key An Um

Yong Youn Hwang

Jae Sun Kim

Joon-Gyo Oh

Won-No Youn

Hyun Joo Son

Young Ah Shin

Joon Ho Sa

Ho Soon Lee

Woo Jae Jang

Hong Kee Sah

Hong-Kee Kim

Shin Ae Kim

Jin-Heung Sung

Ho Chul Shin

Joon Gyo Oh

Hye Young Han

Yong Hyuk Kim

Woong Sik Kim

Seok-chan Kang

Keun Ho Ryu

Seok Hyun Hong

Key-An Um

Seok-Chan Kang

The present invention provides a pharmaceutical composition with improved stability, comprising a fusion protein comprising Factor VII (FVII) and transferrin, as an active ingredient, wherein the transferrin is linked to the C-terminus of the FVII; and trehalose or glycine as a bulking agent. The composition can store FVII and a variant thereof stably at room temperature for a long period of time. Thus it can be used as a useful therapeutic agent for patients suffering from hemophilia or congenital FVII deficiency.

Pharmaceutical composition with improved stability containing factor VII fusion protein

Provided are picolinamide and pyrimidine-4-carboxamide compounds, a method for preparing the same, a pharmaceutical composition containing the same, and a medical use using the compound as an agent for preventing, regulating, and treating diseases related to regulation of glucocorticoids by using selective inhibitory activity of the compound for an 11&#x3b2;-HSD1 enzyme. The picolinamide and pyrimidine-4-carboxamide compounds of the present invention are selective inhibitors of human-derived 11&#x3b2;-HSD1 enzymes, and are useful in an agent for preventing, regulating, and treating diseases related to glucocorticoid regulation in which human-derived 11&#x3b2;-HSD1 enzymes are involved, for example, metabolic syndromes such as, type 1 and type 2 diabetes, diabetes later complications, latent autoimmune diabetes adult (LADA), insulin tolerance syndromes, obesity, impaired glucose tolerance (IGT), impaired fasting glucose (IFG), damaged glucose tolerance, dyslipidemia, atherosclerosis, hypertension, etc.

Picolinamide and pyrimidine-4-carboxamide compounds, process for preparing and pharmaceutical composition comprising the same

The present invention relates to a stable pharmaceutical composition for injection containing docetaxel and a method of preparing the same. More particularly, the present invention relates to a pharmaceutical composition for injection containing docetaxel having better storage stability than conventional medications, which is prepared by dissolving docetaxel, a water-insoluble compound, in distilled water after mixing it with cyclodextrin (CD) and a water-soluble polymer such as hydroxypropyl methylcellulose (HPMC), polyethylene glycol (PEG) or polyvinylpyrrolidone (PVP) and lyophilizing the mixture, and a method of preparing the same.

Stable pharmaceutical composition containing docetaxel and a method of manufacturing the same

Growing community of inventors

Yongin-si, South Korea

Yoon-Jung Lee