Shanghai Meizer Pharmaceuticals Co., Ltd.

Shanghai Institute of Pharmaceutical Industry

China State Institute of Pharmaceutical Industry

Yongzhi Shu

Bin Zhou

Jun Lin

Quanhai Liu

Haifeng Hu

Baoquan Zhu

Provided is a compound for inhibiting and degrading anaplastic lymphoma kinase ALK. Specifically provided is a compound as represented by the following formula I, wherein the definition of each group is as stated in the description. The compound has excellent anaplastic lymphoma kinase (ALK) inhibitory activity, and can be used for preparing drugs for treatment of ALK activity-related diseases.

Compound for inhibiting and degrading tyrosine protein kinase ALK

A compound for inhibiting and degrading cyclin-dependent kinase (CDK) is disclosed. The compound is a substituted glutarimide represented by formula I. The compound can be used in the preparation of drugs for treating diseases related to the activity of the CDK. 

Substituted glutarimides as CDK inhibitors

A compound for inhibiting and degrading Bruton's tyrosine kinase (Btk) is disclosed. The compound is a substituted glutarimide represented by Formula I'. The compound can be used in the preparation of drugs for treating Btk activity-related diseases. 

Substituted glutarimides as Btk inhibitors

Disclosed are a platinum (II) compound, a preparation method therefor, and a pharmaceutical composition and an application thereof. The preparation method comprises the following steps: enabling dihydrate diammine platinum nitrate (4) to react with the carboxylate ligand derivative (5) in water, to produce a platinum (II) compound. Also provided are an application of the platinum (II) compound in preparation of an antitumor drug, and a pharmaceutical composition. The pharmaceutical composition contains an active component and a medicinal carrier, the active component containing the platinum (II) compound, and the mass percentage of the active component being 0.1%-95%. The platinum (II) compound of the present invention is well water-soluble, low toxic, easily prepared, and efficient in antitumor activity. 

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Shanghai, China

Yongzhi Shu