Institute of Pharmacology and Toxicology Academy of Military Medical Sciences Pla China

Institute of Pharmacology

Toxicology Academy of Military Medical Sciences P.l.a., China

Yongzhen Li

Nan Zhao

Yunfeng Li

Liuhong Yun

Rifang Yang

Youzhi Zhang

Juanjuan Qin

Peng Li

Cheng Zhang

Rui Xue

Rusheng Zhao

Hongxia Chen

Zhenzhen Wang

Li Yuan

Jiazhi Yao

Zhongyao Feng

Zengliang Jin

Xiaodan Xu

Zengling Jin

Disclosed are 2-arylimidazo[1,2-a]pyridine-3-acetamide derivatives represented by formula I, their tautomer, racemate or optical isomer, their pharmaceutically acceptable salt, or their solvates, wherein R, R, Rand Rare defined as in the specification. Preparation methods of said compounds and use of said compounds in treating and/or preventing central nervous system disease associated with TSPO functional disorder 

2-aryl imidazo[1,2-a]pyridine-3-acetamide derivatives, preparation methods and uses thereof

Provided are N-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives represented by formula I, stereoisomers, pharmaceutically acceptable salts or solvates thereof.  The above compounds have the dual activities of 5-hydroxytryptamine 1A receptor ligand and selective serotonin reuptake inhibitor. The preparation methods of the above compounds, the uses of these compounds for the prevention or treatment of nervous system diseases related to 5-hydroxytryptamine system dysfunction and the pharmaceutical compositions containing these compounds are also provided.

1-[(4-hydroxypiperidin-4-yl)methyl]pyridin-2(1H)-one derivatives, preparation methods and uses thereof

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Beijing, China

Yongzhen Li