Kent State University

Case Western Reserve University

Yongxiu Li

Songping D Huang

James P Basilion

Christopher A Flask

Mohammadreza Shokouhimehr

Jihua Hao

An agent for imaging of a biological system or delivering drugs to a biological system including one or more nanoparticles formed of at least one gadolinium coordination polymer.

Nanoparticles based on gadolinium coordination polymers as highly sensitive T1 MRI contrast agents

Gadolinium(Gd) containing (or incorporated) Prussian blue lattice contrast agents that can be used as an MRI contrast agent have unexpectedly improved rrelaxivities of 1 or 2 magnitudes higher than the commercial Gd-chelates as well as exceedingly, non-toxic, low release of the Gdions into an aqueous environment at a pH of about 2 to about 7.5. The Prussian blue lattice containing Gdions therein can be used for clinical diagnosis intravenously to human beings for medical imaging. The particle sizes of the doped Prussian blue lattices are of a nanosize scale and are very stable against agglomeration.

Gadolinium containing prussian blue nanoparticles as nontoxic MRI contrast agents having high relaxivity

Growing community of inventors

Kent, OH, United States of America

Yongxiu Li