Hutchison Medipharma Enterprises Limited

Hutchison Medipharma Limited

Yongxin Ren

Wei-Guo Su

Weihan Zhang

Yumin Cui

Xiaoqiang Yan

Jifeng Duan

Hong Jia

Yang Sai

Zhenping Wu

Wenji Li

Haibin Yang

Zhenping Tian

Jiangyong Shao

Provided are certain quinazoline compounds, compositions thereof and methods of use thereof. These quinazoline compounds can effectively inhibit the overexpression and/or overactivity of epidermal growth factor receptor (EGFR).

Quinazoline compounds

Compound of Formula A and pharmaceutically acceptable salts thereof and crystalline Forms I and II of Compound of Formula A! Also, methods for the preparation of such compounds, pharmaceutical compositions comprising such compounds, and methods for their uses.

Compound, certain novel forms thereof, pharmaceutical compositions thereof and methods for preparation and use

A compound of the following formula: wherein R, R, R, R4, R5, T, U, V, X, Y, Z, G, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder, e.g., cancer or age-related macular degeneration, with such a compound.

Pyrimidine derivatives

Quinazoline derivatives of the following formula: wherein R, R, R, R, R, R, R, R, R, R, X, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder with one of these compounds.

Use of substituted quinazoline compounds in treating age-related macular degeneration

Quinazoline derivatives of the following formula: wherein R, R, R, R, R, X, Y, and Z are defined herein. It also discloses a method of treating cancer with one of these compounds.

Quinazoline derivatives

Use of substituted quinazoline compounds in treating angiogenesis-related diseases

Substituted quinazoline compounds of the following formula: wherein R, R, R, R, R, R, R, R, R, R, and X are defined herein. It also discloses a pharmaceutical composition containing one of these compounds.

Growing community of inventors

Shanghai, China

Yongxin Ren