Zhejiang Hisun Pharmaceutical Co., Ltd.

Yongxiang Gong

Hua Bai

Xuyang Zhao

Qifeng Zhu

Jinqing Zhong

Xiaoyu Liu

Lifei Liu

Xiaohe Zheng

Weiwei Liu

Ya Zhou

Xinlong Zhang

Qixian Zhou

Disclosed are a method for preparing a benzodioxole derivative (AD-35) shown by Formula (I) and an intermediate thereof. The method of the present invention involves: using piperic acid as a raw material; and performing bromination, esterification, cyanidation, cyclopropane lactamization, amide nitrogen alkylation, deprotection, piperidine nitrogen alkylation and salification to obtain the compound of Formula (I). The method has cheap and easily available start raw materials, short synthesis routes and simple operation, and is suitable for industrial production. 

Process for preparing AD-35

Provided in the present invention are novel benzodioxole derivatives and preparation methods thereof. These compounds represented by formula (I) or pharmaceutically acceptable salts thereof have acetylcholinesterase inhibitory activity, so can be used in the treatment or prevention of Alzheimer's disease. The definitions of R, Rand A of formula (I) can be seen in the description. 

Benzodioxole derivative and preparation method and use thereof

Provided are a benzamide derivative as shown in formula (I) or a pharmaceutically acceptable salt thereof, and the preparation method and use thereof for preparing a medicine for treating cancer, wherein the group definitions of formula (I) are as set out in the description. 

Benzamide derivative with anticancer activity and preparation method and use thereof

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Taizhou, China

Yongxiang Gong