Novartis Ag

Chinese Academy of Sciences

Yongshuai Chai

Wei Guo

Mahavir Prashad

Yugang Liu

Sven Erik Godtfredsen

Zhaoyin Wang

Mark Kagan

Saijie Zhu

Sven Erik Godtfredson

Mahavar Prashad

The present disclosure provides a compound of Formula (I);  or a pharmaceutically acceptable salt thereof, wherein Rand Rare defined herein. The disclosure also relates to a method for manufacturing the compounds of the disclosure, and its therapeutic uses. The present disclosure further provides pharmaceutical composition of the compounds of the disclosure and a combination of pharmacologically active agents and a compound of the disclosure.

Substituted bisphenyl butanoic ester derivatives as NEP inhibitors

The present disclosure provides a compound of Formula (I); 

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Shanghai, China

Yongshuai Chai