Agios Pharmaceuticals, Inc.

Genentech, Inc.

Rqx Pharmaceuticals, Inc.

Shanghai Ace Cooling Refrigeration Technology Co., Ltd.

Yongsheng Chen

Francesco Gerald Salituro

Jeffrey O Saunders

Jeremy Mark Travins

Janeta Popovici-Muller

Rene Marc Lemieux

Fei Wang

Jun Liang

Yi Yang

Steven Huy Do

Jacob Bradley Schwarz

James John Crawford

Prasuna Paraselli

Robert Higuchi

Emily J Hanan

Kwong Wah Lai

Naomi S Rajapaksa

Michael F T Koehler

Cuong Q Ly

Joy Drobnick

Toby Jonathan Blench

Marian C Bryan

Alberto Gobbi

Peter Andrew Smith

Zhiguo Liu

Tucker Curran Roberts

Paul Colin Michael Winship

James Richard Kiefer, Jr

John Wai

Huiyong Hu

Liqiang Fu

Tamiko Katsumoto

Zhiyong Yu

Jing Zeng

Robert I Higuchi

Calum McCleod

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (SpsB), an essential protein in bacteria. Pharmaceutical compositions and methods for treatment using the compounds described herein are also provided.

Macrocyclic broad spectrum antibiotics

Compounds of Formula I, Formula II, Formula III, Formula IV, Formula V, Formula VI, Formula VII, Formula VIII, and methods of use as Interleukin-1 Receptor Associated Kinase (IRAK4) inhibitors are described herein.

Pyrazolo[ 1,5a]pyrimidine derivatives as IRAK4 modulators

A water distribution system with wide-range variable traffic includes a water distribution tank and at least two types of spray heads uniformly distributed on the bottom of the water distribution tank. Each spray head is provided with a spray pipe connected to the bottom of the water distribution tank. A water inlet is arranged on the upper part of each spray pipe, and a water outlet is arranged on the lower part of the spray pipe. The heights, by which water inlets of at least two types of spray heads are exposed out of the bottom of the water distribution tank, are different.

Water distribution system with wide-range variable traffic

Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.

Compounds and their methods of use

Provided are compounds of formula (I), which can inhibit glutaminase. Pharmaceutical compositions comprising these compounds and uses as glutaminase inhibitors for treating cancers thereof are also provided. 

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Shanghai, China

Yongsheng Chen