Neurocrine Biosciences, Inc.

Almirall, S.a.

Yongsheng Chen

Zhiqiang Guo

Charles Q Huang

Chen Chen

Warren Stanfield Wade

Dongpei Wu

Wesley J Dwight

Martin W Rowbottom

Manisha Moorjani

Jaimie Karyn Rueter

Fabio C Tucci

Marion Lanier

Yun-Fei Zhu

Collin Regan

Deborah Slee

Xiaohu Zhang

Binh G Vong

Emily Lin

GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R, R, R, R, R, R, R, R, Rand X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

Gonadotropin-releasing hormone receptor antagonists and methods related thereto

Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein n, R, R, R, R, R, R, R, R, Rand X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

GnRH receptor antagonists are disclosed that have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure:wherein n, R, R, R, R, R, R, R, R, Rand X are as defined herein, including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

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San Diego, CA, United States of America

Yongsheng Chen