University of Georgia Research Foundation Inc

Emory University

Other

Pharmasset, Inc.

Yale University

Yongseok Choi

Chung K Chu

Raymond F Schinazi

Dennis C Liotta

Yung-Chi Cheng

Junxing Shi

J Jeffrey McAtee

Kyeong Lee

Joon H Hong

Jinfa Du

Michael J Otto

Ling Li

Giuseppe Gumina

Youhoon Chong

2'-Fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein

2' Fluoronucleosides

2'-fluoronucleosides

2-fluoronucleosides

A class of 2'-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formula: wherein

A class of 2'-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae: wherein

2'-Fluoronucleosides

The present invention includes compounds and compositions of &#x3b2;-halonucleosides, as well as methods to treat HIV, HBV or abnormal cellular proliferation comprising administering said compounds or compositions.

&#x3b2;-2'- or 3&#x2032;-halonucleosides

A class of 2'-fluoro-nucleoside compounds are disclosed which are useful in the treatment of hepatitis B infection, hepatitis C infection, HIV and abnormal cellular proliferation, including tumors and cancer. The compounds have the general formulae:wherein

The present invention relates to a novel and improved process for preparing 2'-fluoro-5-methyl-&#x3b2;-L-arabinofuranosyluridine represented by formula (1) which shows anti-viral activity, especially potent anti-viral activity against hepatitis B-virus and Epstein-Barr virus:

Process for the preparation of 2'-fluoro-5-methyl-beta-L-arabino-furanosyluridine

The present invention relates to a novel and improved process for preparing 2&prime;-fluoro-5-methyl-&bgr;-L-arabinofuranosyluridine represented by formula (I) which shows anti-viral activity, especially potent anti-viral activity against hepatitis B-virus and Epstein-Barr virus:

Growing community of inventors

Athens, GA, United States of America

Yongseok Choi