Changzhou No. 4 Pharmaceutical Factory Co., Ltd

Utopharm (shanghai) Co., Ltd

Beijing Do-pharma Tech Co. Ltd

Utopharm Co., Ltd.

Yongrui Tu

Li Xiao

Pengfei Li

Junzhi Luo

Xinhua Fan

Sujing Zhuang

Longhao Wu

Peng Peng

Xiang Zhang

Yun He

Yanyuan Zhang

Mingxia Qian

Zhaojun Wang

Yimin Yan

Xun Luo

Yongqiang Sun

The present invention provides a method for improving the stability of pramipexole or its salt preparation, and further provides a pramipexole hydrochloride oral liquid with excellent stability and oral absorption effect. The pramipexole hydrochloride oral liquid of the present invention is prepared through a simple process, and shows bioequivalence with the tablet containing pramipexole hydrochloride. The invention perfectly realizes multi-dose administration of pramipexole hydrochloride and improves the compliance and accessibility of medication for patients.

Pramipexole hydrochloride oral liquid

A method as well as new intermediates for preparing Ulipristal acetate (a compound I) and a method for preparing the new intermediates are provided. The intermediate in a constitutional formula IV is conductive to reacting with methyl lithium or methyl Grignard reagent, a protective group is easy to be removed after a reaction, side reactions are few, a mid-term treatment is simple, the reagents used are cheap, costs are low and a yield is high, if a compound in a constitutional formula V is obtained by the reaction of a compound in a constitutional formula III and the intermediate in the constitutional formula IV, the yield of a two-step reaction is 75%, a purity is above 98%. wherein R is defined in the specification.

Method for preparing ulipristal acetate and key intermediate thereof

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Jiangsu, China

Yongrui Tu