Nanjing Chuangte Pharmaceutical Technology Co., Ltd.

Nanjing Sanhome Pharmaceutical Co., Ltd.

Shenzhen Jikang Pharmaceutical Technology Co., Ltd.

Zhejiang University

Zhejiang Nhu Company Ltd.

Shangyu Nhu Biological Chemical Co., Ltd.

Yongqiang Zhu

Zhaogang Liu

Chao Feng

Wei Dong Chen

Yong Wang

Yang Yang

Liwen Zhao

Jie Wang

Hongwei Yu

Hao Chen

Jia Wang

Liang Jin

Yanan Zhang

Meng Lei

Luwei Han

Wenming Wu

Qifeng Song

Haoyang Zhang

Ou Hai

Jingmiao Shi

Enhe Bai

Shihe Hu

Shaofeng Chen

Hongmei Zhang

Jianbo Chen

Weifeng Li

Yong Lv

Yong Li

The present invention discloses a tripeptide propylene oxide derivative or a pharmaceutically acceptable salt thereof, and a preparation method and application thereof. The structure of the tripeptide propylene oxide derivative is shown in formula I. Compared with the prior art, the present invention provides tripeptide epoxy ketone compounds with a novel structure and a function of inhibiting proteasome. As 20S proteasome inhibitors, the tripeptide epoxy ketone compounds can block tumor cell proliferation and induce tumor cell apoptosis, so the tripeptide epoxy ketone compounds can be used for the treatment and prevention of a plurality of human and animal diseases such as malignant tumors, and the effect is significantly better.

Tripeptide propylene oxide derivative and preparation method and application thereof

The present disclosure relates to the technical field of antibody drugs, and in particular, to an anti-CD47 antibody or an antigen-binding fragment thereof, a pharmaceutical composition comprising the anti-CD47 antibody or the antigen-binding fragment thereof, and applications thereof. The anti-CD47 antibody or the antigen-binding fragment thereof has significant antitumor activity and high affinity with human CD47 protein, can eliminate the capability of SIRPa to bind to CD47 on a surface of a cell, and does not have significant hemoagglutination activity and thus can be applied to the preparation of an anti-tumor drug.

Anti-CD47 antibody and application thereof

Disclosed in the present invention are a crystal form of monomethanesulfonate of a deuterated 3-(4,5-substituted aminopyrimidine)phenyl compound as represented by formula I, and a preparation method therefor. The crystal form is highly stable, can be used for treatment or prevention of diseases or conditions by means of epidermal growth factor receptors (EGFRs) in some mutation forms, can effectively inhibit the growth of a variety of tumor cells, and have an inhibiting effect on other proteases of EGFR and Her families, and thus can be used for preparing antitumor drugs.

Crystal form of monomethanesulfonate of deuterated 3-(4,5-substituted aminopyrimidine)phenyl compound and preparation method therefor

A type of deuterated 3-(4,5-substituted aminopyrimidine)phenyl derivatives and use thereof. The derivatives are compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds or salts thereof can be used for treatment or prevention of diseases or illnesses through certain mutant forms of epidermal growth factor receptors, inhibit the growth of various tumor cells effectively, and inhibit other proteases of EGFR and Her families, they can be used for preparing anti-tumor drugs.

Deuterated 3-(4,5-substituted aminopyrimidine)phenyl derivatives and use thereof

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Nanjing, China

Yongqiang Zhu