Shanghai Medicilon Inc.

Medicilon Preclinical Research (shanghai) Llc.

Yongmei Xu

Feng Ren

Chunlin Chen

Jinna Cai

Xianlian Wang

A class of substituted pyrrolo[3,4-c]pyrazoles for treating gastric acid-related diseases is described as represented by the following formula (I):

Substituted pyrrolo[3,4-c]pyrazoles for treating gastric acid-related diseases

A novel type of pyrrolopyrazole derivatives shown in general formula (I), a preparation method thereof and application thereof or a pharmaceutical composition containing same as a therapeutic agent, particularly as a gastric acid secretion inhibitor and a potassium-competitive acid blocker (P-CABs) in biomedicine.

Pyrrolopyrazole derivatives, preparation method thereof and application thereof in medicine

Disclosed are a pyrrolopyrazole derivative, a preparation method therefor, and the medical use thereof. In particular, disclosed are a novel class of pyrrolopyrazole derivatives represented by general formula (I), a preparation method therefor, and the use of the pyrrolopyrazole derivatives or pharmaceutical compositions containing the pyrrolopyrazole derivatives in biomedicine as therapeutic agents, particularly as gastric acid secretion inhibitors and potassium ion competitive acid blochers (P-CABs). The definitions of various substituent (R, R, R, R) and the group (X) in general formula (I) are the same as the definitions in the description.

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Shanghai, China

Yongmei Xu