Genentech, Inc.

Yonglei Shang

Isidro Hotzel

Jagath Reddy Junutula

Jo-Anne Hongo

Meredith C Hazen

Shang-Fan Yu

Sunil Bhakta

The present invention relates to polypeptide expression systems and methods of using the same.

Polypeptide expression systems

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. In certain aspects, the isolated nucleic acid molecule comprises a nucleotide sequence having at least about 80% nucleic acid sequence identity, alternatively at least about 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% nucleic acid sequence identity, to (a) a DNA molecule encoding a full-length TAT polypeptide having an amino acid sequence as disclosed herein, a TAT polypeptide amino acid sequence lacking the signal peptide as disclosed herein, an extracellular domain of a transmembrane TAT polypeptide, with or without the signal peptide, as disclosed herein.

Compositions and methods for the diagnosis and treatment of tumor

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Millbrae, CA, United States of America

Yonglei Shang