Massachusetts Institute of Technology

University of Alberta

Harvard College

Yongku Peter Cho

Edward Stuart Boyden

Nathan Klapoetke

Brian Yichiun Chow

Gane Ka-Shu Wong

Fei Chen

Adam Ezra Cohen

Daniel Hochbaum

Amy S Chuong

Gane K S Wong

The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of light-activated ion channels.

Channelrhodopsins for optical control of cells

CsChrimson light-activated ion channel polypeptides, their encoding polynucleotides, and variants thereof are provided. Methods of introducing and using CsChrimson light activated ion channels and variants thereof for to alter cell activity and function are also provided.

Channelrhodopsin variants and uses thereof

The invention, in some aspects relates to compositions and methods for altering cell activity and function and the introduction and use of mutant light-activated ion channels and variants thereof.

Mutant channelrhodopsins with altered ion selectivity

The invention, in some aspects relates to light-activated ion channel polypeptides and encoding nucleic acids and also relates in part to compositions comprising light-activated ion channel polypeptides and methods using light-activated ion channel polypeptides to alter cell activity and function.

Blue-light-activated ion channel polypeptides and uses thereof

Growing community of inventors

Vernon, CT, United States of America

Yongku Peter Cho