Hammersmith Imanet Limited

Yongjun Zhao

Sajinder Kaur Luthra

Frank Brady

The invention relates to a process for the production of an [F]fluorohaloalkane which comprises treatment of a solid support-bound precursor of formula (I):SOLID SUPPORT-LINKER-SO&#x2014;O&#x2014;(CH)X&#x2003;&#x2003;(I)wherein n is an integer of from 1 to 7 and X is chloro, bromo or iodo;withFto produce the [F]fluorohaloalkane of formula (II)F&#x2014;(CH)&#x2014;X&#x2003;&#x2003;(II)wherein n and X are as defined for the compound of formula (I), optionally followed by

[object Object]

The invention provides a process for preparation of a fluorohaloalkane, preferably an [F]fluorohaloalkane of formula (I) wherein X is halo and n is an integer of from 1 to 6; which comprises: reaction of the corresponding organosilicon compound of formula (II): wherein n is as defined for the compound of formula (I); and R', R&#x2033;, and R&#x2032;&#x2033; are independently selected from Calkyl and Chaloalkyl; and R&#x2033; may alternatively be the group: with a compound of formula (III): wherein X is as defined for the compound of formula (I) and Y is halo. Intermediates having use in such processes are also claimed. 

Chemical process

The invention relates to a process for the production of an [F]fluorohaloalkane which comprises treatment of a solid support-bound precursor of formula (I): SOLID SUPPORT-LINKER-SO&#x2014;O&#x2014;(CH)X (I) wherein n is an integer of from (1) to (7) and X is chloro, bromo or iodo; withFto produce the [F]fluorohaloalkane of formula (II)F&#x2014;(CH)&#x2014;X (II) wherein n and X are as defined for the compound of formula (I), optionally followed by (i) removal of excessF, for example by ion-exchange chromatography; and/or (ii) removal of organic solvent.

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London, United Kingdom

Yongjun Zhao