Tsinghua University

Yonghua Xie

Xin Li

Ke Wang

Meng Zhao

Yonghui Zhang

Liping Li

Yun Xia

Zhengsen Yu

Wanli Liu

Xiaoying Zhou

Yunyun Yang

Kanzhao Gao

Disclosed are inhibitors of mevalonate pathway as an efficient vaccine adjuvant and use thereof. In particular, the inhibitor is an acetoacetyl-CoA transferase inhibitor, a HMG-CoA synthase inhibitor, a HMG-CoA reductase inhibitor, a mevalonate kinase inhibitor, a phosphomevalonate kinase inhibitor, a mevalonate-5-pyrophosphate decarboxylase inhibitor, an isopentenyl pyrophosphate isomerase inhibitor, a farnesyl pyrophosphate synthase inhibitor, a geranylgeranyl pyrophosphate synthase inhibitor or a geranylgeranyl transferase (I, II) inhibitor. Also disclosed is an immunogenic composition comprising inhibitors of mevalonate pathway as an adjuvant.

Mevalonate pathway inhibitor as highly-efficient vaccine adjuvant

Growing community of inventors

Beijing, China

Yonghua Xie