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Anhui New Star Pharmaceutical Development Co., Ltd.

Yonghai Zhao

Feng Li

Yong He

Ziao Xu

Degang Li

Xiaoxiang Li

Guangwei He

Jiaming Li

Fengshi Ma

Qiang Wu

Yumei Xu

Genling Jiang

A P2Y12 receptor antagonist containing a guanidyl, and a preparation method and the use thereof. In particular, the present disclosure provides a pyridazinone-guanidine compound that is a compound of structural formula (I), or a stereoisomer of the above-mentioned compound, a pro-drug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof. Such a compound has multiple pharmacological activities, especially has an inhibitory effect on platelet aggregation, and can be used for preparing an anti-platelet aggregation pharmaceutical composition.

Guanidyl-containing P2Y12 receptor antagonist and preparation method and application thereof

Ligustrazine aromatic acid ether derivative of general formula I, its preparation method, pharmaceutical composition and application, wherein Ar is selected from aryl substituted aryl and substituted styryl, R is selected from hydrogen and alkyl with no more than 6 carbon atoms. 

4-((3, 5, 6-trimethylpyrazine-2-yl) methoxyl) benzoic acid and its derivatives

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Hefei, China

Yonghai Zhao