Systimmune, Inc.

Baili-bio (chengdu) Pharmaceutical Co., Ltd.

Chengdu Kanghong Pharmaceutical Co., Ltd.

Yongguo Yu

Yi Zhu

Jie Li

Shi Zhuo

Lan Chen

Zunhong Ke

Yiqian Wang

Weijia Liu

Yixi Wang

Weili Wan

Disclosed is a non-natural amatoxin-type antibody conjugate, said conjugate similar to the natural amatoxin is linked to a biopharmaceutically acceptable salt with a target biomolecule so as to obtain stability in blood plasma, and efficiently kill tumor cells in cells.

Non-natural amatoxin-type antibody conjugate

By inserting cysteine (C) into a heavy chain and/or a light chain of a target antibody at specific insertion site, and performing a site-specific conjugation through a free thiol group (&#x2014;SH) from the site-specific inserted cysteine and a linker conjugated with a highly potent small molecule cytotoxin, a cysteine modified antibody-drug conjugate with good homogeneity is provided. The specific insertion sites of cysteine are position 205 and/or position 206 (Kabat numbering scheme) of the light chain of the antibody, and/or position 439 (Kabat numbering scheme) of the heavy chain.

Cysteine modified antibody-drug conjugate and preparation method thereof

Growing community of inventors

Chengdu, China

Yongguo Yu