Nanyang Technological University

University of California

California Institute of Technology

Yonggui Chi

Jean M J Frechet

Mamadou Samba Diallo

Emine Boz

Zhenqian Fu

Bhoopendra Tiwari

Zhijian Huang

Disclosed herein is a method of forming a compound of formula I: wherein the substituents are defined in the specification. In particular, the compounds of formula I can be converted to amino acids bearing quaternary stereocenters with exceptional optical purities.

Highly enantioselective access to cyclic beta-amino acids

The present invention relates to a method for synthesizing a compound of Formula (I)    

Activation of carbonyl beta-carbons for chemical transformations

Present invention relates to a method of preparing a chiral &#x3b1;- or &#x3b2;-substituted ketone from the corresponding &#x3b2;- or &#x3b3;-substituted aldehyde, wherein the ketone has formula (I), (III) or (V), and the corresponding aldehyde has formula (II), (IV) or (VI), respectively, the method comprising reacting the aldehyde of formula (II), (IV) or (VI) in the presence of an amine, oxygen and an organic solvent, wherein the reaction is carried out in the absence of a metal-based catalyst or a metal-based oxidant, wherein: R is H, a substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, substituted or unsubstituted C-Ccycloalkyl, substituted or unsubstituted C-Ccycloalkenyl, substituted or unsubstituted C-Cheterocycloalkyl, substituted or unsubstituted C-Cheterocycloalkenyl, substituted or unsubstituted C-Caryl, or substituted or unsubstituted C-Cheteroaryl; and R' is H, a substituted or unsubstituted C-Calkyl, substituted or unsubstituted C-Calkenyl, substituted or unsubstituted C-Calkynyl, substituted or unsubstituted C-Ccycloalkyl, substituted or unsubstituted C-Ccycloalkenyl, substituted or unsubstituted C-Cheterocycloalkyl, substituted or unsubstituted C-Cheterocycloalkenyl, substituted or unsubstituted C-Caryl, or substituted or unsubstituted C-Cheteroaryl. 

Method of preparing chiral ketones from aldehydes

Hyperbranched macromolecules and methods are described for selectively filtering contaminants such as anions from water and non-aqueous solutions, particularly in the presence of competing contaminants including other anions. The hyperbranched macromolecules may contain alkyl, 2-hydroxyalkyl, 2-methyl-2-hydroxylalkyl, 2-hydroxy-2-phenylalkyl, and other groups, which may be hydrophilic or hydrophobic. The molecules may preferentially bind to the contaminant at interest at low pH, and release the contaminant at a pH of about 9. The molecules may be used to filter contaminants including perchlorate and nitrate even in the presence of high sulfate concentrations.

Growing community of inventors

Singapore, Singapore

Yonggui Chi