Shanghai Jiao Tong University

Zte Corporation

Lansus Technologies Inc

Jiangsu Jibeier Pharmaceutical Co. Ltd.

Yongfeng Zhou

Wei Huang

Xinyuan Zhu

Deyue Yan

Ping Huang

Qi Wang

Yao Wang

Jiashuai Guo

Lei Yan

Zhongyi Geng

Mingshi Sun

Zhenli Yang

Rongqin Yan

An LDO power supply circuit includes an operational amplifier, a first transistor, and a resistance feedback network including a first branch and a second branch. A negative electrode input end of the operational amplifier connects a control voltage. An output end of the operational amplifier connects a gate electrode of the first transistor. A source electrode of the first transistor connects a power supply voltage. A positive electrode input end of the operational amplifier and a drain electrode of the first transistor are respectively an input end and an output end of the LDO power supply circuit. The resistance feedback network connects between the drain electrode of the first transistor and the positive electrode input end of the operational amplifier. A first feedback coefficient formed by the first branch is different from a second feedback coefficient formed by the second branch. The present disclosure further provides a power amplifier.

LDO power supply circuit and power amplifier

The present disclosure provides a ketone carbonyl-containing hydrophobic antitumor drug and a conjugate thereof as well as a nano preparation containing the conjugate, a preparation method therefor, and an application thereof. The conjugate is an amphipathic pH-responsive conjugate obtained by enabling a dehydration condensation reaction between a hydrazide-terminated polyethylene glycol and/or lactose hydrazide and the ketone carbonyl-introduced hydrophobic antitumor drug. The ketone carbonyl-introduced hydrophobic antitumor drug is obtained by reacting an isocyanate group in a compound containing isocyanate group and ketone carbonyl group with a hydroxyl on a hydroxyl-containing hydrophobic antitumor drug. The hydroxyl-containing hydrophobic antitumor drug includes at least one of paclitaxel, docetaxel, paclitaxel derivatives, or docetaxel derivatives. Compared with docetaxel, the ketone carbonyl-containing hydrophobic antitumor drug, the conjugate thereof and the nano preparation have higher antitumor activity.

Ketone carbonyl-containing hydrophobic antitumor drug and conjugate thereof as well as nano preparation containing conjugate, preparation method therefor, and application thereof

The invention provides novel amphiphilic drug-drug conjugates useful as cancer therapeutics, and compositions and methods thereof.

Amphiphilic drug-drug conjugates for cancer therapy, compositions and methods of preparation and uses thereof

An optical line terminal (OLT) device and an implementation method thereof, relate to the field of a passive optical network (PON). The OLT device includes an interface unit for receiving data in an Ethernet format sent by a service processing apparatus, performing protocol processing on the received data in the Ethernet format, converting the data after the protocol processing into a transmission signal corresponding to a sending interface, and then transmitting the transmission signal to an external device, as well as receiving message data sent by the external device, converting the message data for protocol processing corresponding to the service processing apparatus, converting the signal after the protocol processing into data in the Ethernet format, and transmitting the data to the service processing apparatus; the service processing apparatus performing service processing on the data transmitted by the interface unit, and transmitting the processed data to the interface unit.

Optical line terminal device and implementation method thereof

Growing community of inventors

Shanghai, China

Yongfeng Zhou