Genentech, Inc.

Chinese Academy of Sciences

Shanghai Jemincare Pharmaceuticals Co., Ltd.

Jiangxi Jemincare Group Co., Ltd.

Yongcong Lv

Haibing Guo

Weiqiang Xing

Jianbiao Peng

Hongfu Lu

Baojian Qi

Jian Ding

Hua Xie

Wenhu Duan

Disclosed are a phthalazinone compound, and a preparation method therefor and the medical use thereof. In particular, disclosed are a compound as represented by formula (I), and a pharmacodynamically acceptable salt, and the use of the compound as an androgen receptor (AR) for degradation.

Phthalazinone compound, and preparation method therefor and medical use thereof

The present invention relates to a naphthylamide compound of the structure as represented by formula (I), medicinal salts, prodrugs and hydrates or solvates thereof, and also relates to a method of preparing the compounds, pharmaceutical compositions comprising the compounds and the uses thereof as protein tyrosine kinase inhibitors, particularly as VEGFR-2 inhibitors, in preparing drugs for preventing and treating diseases related to abnormal angiogenesis. 

Naphthylamide compound, preparation method and use thereof

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Shanghai, China

Yongcong Lv