Chinese Academy of Sciences

Chinese Academy of Medical Sciences

Yongchun Yang

Jianjun Zhang

Jiangong Shi

Yafang Wang

Yan Li

Jing Wang

Min Li

Dan Zhang

Sheng Lin

Mei Gao

Ruiming Xu

Jiachen Zi

Xiaona Fan

Zhenggang Yue

Li Sheng

Chenggen Zhu

Shengyang Huang

The present invention provides N-substituted adenosine derivatives and N-substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia. 

[object Object]

The use of extract form Wangla ((L) Hartm. Var.(Willd.) Richter), succinate derivative esters, and a derivative and pharmaceutical acceptable salts thereof, for the manufacture of a pharmaceutical preparation for the treatment of dementia, particularly for the treatment of Alzheimer' disease and Vascular dementia. Through Animal experiment, it has been demonstrated that, succinate derivative esters can improve learning and memory ability in dementia rats induced by scopolamine and cyclohexenyl imine; improve learning and memory ability in dementia rats induced by &#x3b2;-amyloid; improve learning and memory ability in dementia rats induced by permanent ligation of bilateral carotid; and improve memory ability of normal animals. It has the advantage of high activity, low toxicity and no inhibition to cholinesterase.

Use of derivatives of succinate esters for the treatment of dementia

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Beijing, China

Yongchun Yang