Baylor College of Medicine

University of Illinois

University of California

Yongcheng Song

Eric Oldfield

John M Sanders

Bert W O'Malley

David Michael Lonard

Yonghui Zhang

Julian M W Chan

Victor Nizet

George Y Liu

Mary K Estes

Jianming Xu

Timothy Gerald Palzkill

Xiaonan Li

Weei-Chin Lin

Pinki Chowdhury

Gregory E Lin

Kang Liu

Fang-Tsyr Lin

Lei Wang

B Venkataram Prasad

Small molecule stimulators of steroid receptor coactivator-3 (SRC-3) and methods of their use as cardioprotective agents are provided. The small molecule stimulators are useful for promoting cardiac protection and repair and vascular regeneration after myocardial infarction. The compounds are also useful in preventing cardiac hypertrophy and collagen deposition and improving cardiac post-infarction function.

Small molecule stimulators of steroid receptor coactivator-3 and methods of their use as cardioprotective and/or vascular regenerative agents

The present disclosure concerns inhibitors of Norovirus protease that are suitable for use against any genotype of Norovirus, including at least GII.4 Norovirus proteases. In particular embodiments, specific compositions are encompassed, including their use for prevention or treatment of Norovirus infection in an individual.

Structure of GII.4 norovirus protease&#x2014;design of broad-spectrum protease inhibitors

Small molecule stimulators of steroid receptor coactivator (SRC) family proteins are provided, as well as methods for their use in treating or preventing cancer. Also provided are methods for stimulating SRC family proteins in a cell.

Small molecule stimulators of steroid receptor coactivator proteins and their use in the treatment of cancer

The present invention provides a method of treating cancer that overexpresses TopBP1 by administering to a patient suffering from the cancer with an effective amount of a small molecule inhibitor that binds the BRCT7/8 domain of TopBP1.

Method of treating cancer that overexpresses TopBP1

The disclosure provides compounds and methods to treat a microbial or a bacterial pathogenesis, and demonstrates that thepigment is a virulence factor and potential novel target for antimicrobial therapy.

Antimicrobial compositions for treating microbial infections

The disclosure provides compounds and methods to treat bacterial pathogenesis, and demonstrates that thepigment is a virulence factor and potential novel target for antimicrobial therapy.

Antimicrobial therapy for bacterial infections

Bisphosphonate compounds and related methods of making and using are disclosed, including pyridinium-1-yl, quinolinium-1-yl, and related compounds. The activity of compounds is disclosed in the context of functional assays such asfarnesyl diphosphate synthase (FPPS) inhibition,growth inhibition, human gamma delta T cell activation, and bone resorption. The applicability of bisphosphonate compounds in the context of parasitic infections, for example against trypanosomes, is disclosed. Further potential applications of the invention are disclosed regarding the treatment of one or more conditions such as bone resorption disorders, cancer, bone pain, infectious diseases, and in immunotherapy.

Bisphosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases

The invention provides, inter alia, novel bisphosphonate compounds and methods of making and using. In embodiments, the invention provides compounds and methods in connection with research and therapeutic applications, e.g., for tumor cell growth inhibition, activation of gammadelta T cells, inhibition of farnesyldiphosphate (FPPS) and/or undecaprenyldiphosphate synthase enzymes, bone resorption diseases, cancer, immune disorders, immunotherapy, and infectious diseases. In regards to certain embodiments, a surprising advance has been the recognition that certain structural features can significantly enhance the activity of the compounds. For example, the presence of particular cationic species e.g., phosphonium, sulfonium, and arsonium moieties can contribute to desirable functional activity when positioned near a bisphosphonate moiety. In other embodiments of non-nitrogen containing bisphosphonates, terphenyl and benzyl bisphosphonate compounds and methods are provided. Further variations are also provided.

Bisphosphonate compounds and methods

Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases

Growing community of inventors

Pearland, TX, United States of America

Yongcheng Song