Cas Lamvac (Guangzhou) Biomedical Technology Co., Ltd.

Shenzhen Istirbio Co., Ltd.

Yongchao Yao

Xiaoping Chen

Ting Jiang

Li Qin

Wen Hu

Zhu Tao

Yanli Gu

Sha Yin

Guangjie Liu

Youjia Li

Yinbo Jiang

Shuozhou Huang

Jiaojiao Li

Huihui Zhang

Wenzhong Guo

Disclosed by the present application are an antibody library construction method and an application thereof. The method comprises the following steps: inserting a first element and a second element into a same vector or different vectors, and transfecting the vectors into the cells to obtain an antibody expression cell library, i.e., the antibody library. The first element comprises CIS activators and selection marker genes; the second element comprises extracellular antibody library coding domain, Notch nuclear structure domain and intracellular transcription structure domain.

Antibody library construction method and application thereof

Provided are a chimeric antigen receptor and an application thereof; said chimeric antigen receptor contains a domain which identifies any one of, or a combination of at least two of, the malarial protein VAR2CSA, a protein tag on malarial protein VAR2CSA, or a compound capable of labeling the malarial protein VAR2CSA. The chimeric antigen receptor can identify the VAR2CSA protein or the recombinant protein (rVAR2) of any one of, or at least two of, the domains of the VAR2CSA protein which can bind to placental-like chondroitin sulfate A (pl-CSA). The VAR2CSA protein or rVAS2 protein is capable of targeting several different types of tumor cells by means of binding to the pl-CSA on the surface of the tumor cell.

Chimeric antigen receptor and application thereof

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Guangdong, China

Yongchao Yao