Zhejiang Hisun Pharmaceutical Co., Ltd.

Pacific Precision Forging Co., Ltd.

Pacific Precision Powertrain Co., Ltd.

Yong Zhang

Hua Bai

Xuyang Zhao

Yuncai Zhang

Xiaojie Xu

Qifeng Zhu

Jian Zhang

Zhiqing Yang

Xufei Li

Dezhou Xu

Li Zhang

Xiaoming Wang

Zehua Zhong

Xiaohe Zheng

Xiaoyu Liu

Maojian Gu

Hairong Luo

Jun Qin

Hongjun Zhao

Yi Dong

Ying Chen

Hanguan Xia

A checking tool for measuring a distance between adjacent sinking grooves in an inner hole of a mechanical part, including: a gage block, end cover, sliding piece, pin, base, pin seat, support, measuring rod, spring, barrel, and dial indicator. An inner end face of the base is provided with the sliding piece, at least three concentric circular arc grooves are on the end face, paired eccentric arc grooves are on the sliding piece, the pin connected to the pin seat runs through the base and sliding piece, which is axially limited by the end cover, and the seat rotates relative to the base to realize radial expansion displacement of the sliding piece. A measuring head is formed by the dial indicator, measuring rod, spring and barrel. By positioning the edges of adjacent sinking grooves in an inner hole, measurement for a distance between the grooves is converted into depth measurement.

Checking tool for measuring distance between adjacent sinking grooves in inner hole of mechanical part

Disclosed is a new method for preparing an azetidinone compound represented by formula (I). The carboxylic ketoester represented by formula (II) serves as the raw material and is subjected to Grignard addition, stereoselective dehydration, ester group reduction, hydroxyl group protection, addition with imine after condensation with a chiral auxiliary, cyclization and deprotection to obtain the compound represented by formula (I). The present invention has advantages of easily available raw material, a few synthetic steps, simple operation, high yield, good stereoselectivity and low cost, and can be used for industrial production. 

Method for preparing azetidinone compound and intermediate of azetidinone compound

Preparation of azetidinone compounds and medical use thereof are provided by the present invention. More particularly, azetidionne compounds, shown as formula (I), wherein R, R, R, R, Rand Rare defined in description, and preparation methods thereof are provided by the present invention. The compounds of the present invention can reduce the levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in plasma, and can be used as medicaments for reducing cholesterol in blood. Therefore the compounds of the present invention can be used to treat or prevent diseases of atherosclerosis, cacergasia of blood vessel, cardiac failure, coronary artery disease, angiocardiopathy, myocardial, angina, hyperlipoidemia and hypercholesteremia and the like. Preparation method of compounds of formula (I) and intermediate compounds are also provided by the present invention. 

Azetidinone compounds and medical use thereof

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Taizhou, China

Yong Zhang