Suzhou Xianjue New Materials Technology Co., Ltd.

Careray Digital Medical Technology Co., Ltd.

Yong Xu

Fan He

Xinfeng Zhou

Lirong Zhang

Jianqiang Liu

The present disclosure relates to the field of biomaterial technology, and discloses an extracellular matrix hydrogel microsphere and a preparation method thereof. The method includes: constructing a neonatal rat bone marrow mesenchymal stem cell-derived extracellular matrix; preparing hydrogel microspheres by microfluidic technique; and using a condensing agent DMTMM to activate carboxyl groups on surfaces of hydrogel microspheres, and making the activated hydrogel microspheres react with amino groups of the extracellular matrix to obtain extracellular matrix hydrogel microspheres. The present disclosure constructs an extracellular matrix hydrogel microsphere, which realizes the advantage complementary between a hydrogel and a stem cell-derived extracellular matrix, and retains the biocompatibility of a hydrogel precursor material while having mechanical properties. By combining a hydrogel microsphere with an extracellular matrix, bone formation of bone marrow mesenchymal stem cells in vitro may be significantly promoted, and osteoclast differentiation is inhibited, which provides more possibilities for cranial defect repair.

Extracellular matrix hydrogel microsphere, and preparation method and application thereof

An X-ray high-absorptivity detection system and an image imaging method are provided. The system comprises a fluorescent layer, a light source for emitting X-rays towards the fluorescent layer, a first visible light sensor, a second visible light sensor, a first image acquisition device, a second image acquisition device. First visible photons moving towards the first visible light sensor and second visible photons moving towards the second visible light sensor are generated under the excitation of X photons; the first image acquisition device is configured for obtaining a first image signal by the first visible light sensor acquiring a first visible photon signal, and the second image acquisition device is configured for obtaining a second image signal by the second visible light sensor acquiring a second visible photon signal; an X-ray image signal is obtained by an addition operation on the two image signals.

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Suzhou, China

Yong Xu