Sungkwang Medical Foundation

Cmg Pharmaceutical Co., Ltd.

Yong Wha Moon

Hee Jung An

Yeon Ho Choi

Se Wha Kim

Eun Jin Lim

Jin Sung Kim

Albert Charles Gyorkos

Eun Kyung Choi

Jeongbeob Seo

Suk Young Cho

Gilnam Lee

Jung Jin Hwang

Choung Soo Kim

Han Won Cho

Chul Soo Lim

Provided are a composition for culturing NK cells, and a method of culturing NK cells using the same. According to an aspect, in culturing NK cells from peripheral blood mononuclear cells, when NK cells are cultured in a medium including the composition for culturing NK cells, the composition including IL-15, IL-18, and IL-27, the NK cells may proliferate in large quantities and activation of NK cells may be promoted. Therefore, when the NK cells are used, cancer cell apoptosis or cancer cell-killing ability may be promoted. Accordingly, the NK cells may be used as an effective adoptive immune cell therapy product in cancer prevention or treatment.

Composition for culturing NK cells and method for culturing NK cells using same

The invention provides novel substituted pyridopyrimidines represented by Formula I or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of the phosphoinositide 3' OH kinase family (PI3K) for the treatment of inflammatory diseases, cancer, cardiovascular diseases, allergy, asthma and autoimmune disorders. 

Pyridopyrimidine derivatives and use thereof

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Gyeonggi-do, South Korea

Yong Wha Moon