Nanjing Sanhome Pharmaceutical Co., Ltd.

International Business Machines Corporation

Jiangsu University

Huawei Technologies Co., Limited

Nanjing Tech University

Shenzhen Yinwang Intelligent Technologies Co., Ltd.

Montage Technology (kunshan) Co., Ltd.

Longi Solar Technology (taizhou) Co., Ltd.

Institute of Fluid Engineering Equipment, Jitri

Jiangsu Protelight Pharmaceutical & Biotechnology Co., Ltd.

Xidian University

Chen, Yuxin

Yong Wang

Xiang Yu Yang

Deng Xin Luo

Liwen Zhao

Zhong Fang Yuan

Cang Zhang

Ye Wy Wang

Hongyan Chen

Wen Jie Wang

Yan Mei Zhang

Di Zhang

Xiaorong Liu

Houlin Liu

Long Chen

Yingfeng Cai

Zhen Zhu

Xian Zhang

Xiang Tian

Xiaodong Sun

Kai Wang

Ye Chuan Wang

Chaofeng Pan

Liang Dong

Falin Zeng

Yulin Deng

Lingxin Zeng

Sheng Bi

Jiemei Zhou

Dandan Huang

Zilong Zhang

Kaikai Luo

Minggao Tan

Xu Quan

Yiping Gao

Chunhuan Jiang

Dezhong Wang

Yang Nan

Guochuang Zheng

Tao Wu

Yinghui Yu

Li Li

Jing Chen

Hai Jun Wang

De Shuo Kong

Weihong Xing

Yang Liu

Yu Pan

Yazhou Wang

Ming Li

Jun Chen

Yan Zhang

Chao Li

Peng Chen

Qi Liu

Nanping Xu

Hua Li

Qiang Xu

Jianzhao Li

Chen Wang

Jiyu Liu

Feng Wu

Yang Li

Yongqiang Zhu

Ge Liang

Han Ying Song

Haiping Zhou

Changjian Gao

Yunyun Wang

Xueren Yang

Zhi Peng Jia

Zhi Cao

Debao Zhao

Liang Jin

Yanan Zhang

Yu Huang

Yuxin Chen

Mingxia Chen

Yibing Huang

Lili Qu

Wenren Wang

Hongbin Chen

Wenping Zhang

Wen Xiao

Zaijin Teng

Shaozhong Fu

Yanjie Wang

Xinsheng Shi

Yu Ying Y Y Wang

Hongfeng Gu

Silin Pang

Wei Hai

Dinglei Zhong

Bingyang Ge

Jun Guo

Jia Wei He

Zhi Yong Jia

Yanpeng Yang

Dongqing Wang

Yu Ying Yy Wang

The present invention belongs to the field of medicinal chemistry and relates to a class of substituted tricyclic compounds as PRMT5 inhibitors and the use thereof. Specifically, the present invention provides a compound represented by formula (A) or an isomer, pharmaceutically acceptable salt, solvate, crystal or prodrug thereof, a preparation method therefor, a pharmaceutical composition containing the compounds, and the use of the compounds or the composition for treating a disease mediated by PRMT5. The compounds of the present invention show significant inhibitory activity on PRMT5.

Substituted tricyclic compound as PRMT5 inhibitor and use thereof

Folding ramp

A signal processing method for a memory system interface circuit includes: pre-processing a received signal to obtain an input signal; removing a weighted feedback signal from the input signal to obtain an output signal; deciding on the output signal based on a predetermined base signal to generate a digital output signal; generating an interference digital output signal associated with a crosstalk aggressor link; weighting, on a scale of a filter coefficient matrix of the FIR filter, the interference digital output signal to obtain the weighted feedback signal; comparing the output signal with a reference signal to generate an error signal; and determining a set of optimal filter coefficients of the filter coefficient matrix of the FIR filter according to correlation between the interference digital output signal and the error signal, and determining the reference signal according to correlation between the digital output signal and the error signal, to at least partially reduce inter-symbol interference of the received signal introduced by the transmission characteristics of the crosstalk aggressor link.

Signal processing method and device for a memory system interface circuit

Mechanisms are provided for automatically predicting vehicle weight of a moving vehicle. Vehicle operation data is obtained from one or more on-board sensors/systems of the vehicle and features are extracted. The features are filtered based on a required working condition of the vehicle to identify intervals of features having valid feature data to thereby generate a filtered valid data. The filtered valid data is processed by a first artificial intelligence (AI) computer model based on time slices of the filtered valid data to generate a first prediction of vehicle weight, and by a second AI computer model based on buckets of key variables to generate a second prediction of vehicle weight. The first prediction is fused with the second prediction to generate a final prediction of vehicle weight which is output to downstream computing logic.

Estimating moving vehicle weight based on driving data

From a set of point data, a set of scattered rays is constructed. From the set of scattered rays, a set of ray slopes is computed. The set of ray slopes is mapped to a corresponding set of trigonometric functions. Using an optimization method, a parameter of the set of trigonometric functions is selected. Using an inverse of the set trigonometric functions, a vehicle mass corresponding to the set of point data is computed. Based on the vehicle mass, a threshold braking distance of a collision avoidance system of the vehicle is adjusted, the threshold braking distance comprising a distance from an object predicted to collide with the vehicle. By braking the vehicle at least the threshold braking distance from the object, a predicted collision between the vehicle and the object is avoided.

Vehicle mass measurement for automated braking

Embodiments of this application provide a key update method and a related apparatus. One example method includes: sending a first key update request to a second node, where the first key update request includes a first key negotiation parameter and first identity authentication information, and the first identity authentication information is generated by using a first shared key; receiving a first response message from the second node, where the first response message includes second identity authentication information; performing verification on the second identity authentication information by using the first shared key; and if the verification on the second identity authentication information succeeds, determining a first target key based on the first key negotiation parameter.

Key update method and related apparatus

Embodiments of this application provide a security protection method in an in-vehicle system and a device, relate to the field of internet of vehicles technologies, to deploy a first security protection module on an electronic control unit, deploy a second security protection module on a domain controller, and deploy a third security protection module on a gateway based on security level requirements of the gateway, the domain controller, and the electronic control unit, so that the gateway, the domain controller, and the electronic control unit have different security levels. A security level of the first security protection module is a first security level, a security level of the second security protection module is a second security level, and a security level of the third security protection module is a third security level.

Security protection method in in-vehicle system and device

Collapsible bucket

The present disclosure provides a two-stage cavitation generator for organic wastewater treatment, including a shrouded impeller, a stator, and a rotor. The shrouded impeller includes a front cover plate, blades, and a rear cover plate. Several blades are evenly distributed between the front cover plate and the rear cover plate. A working surface of the blade is an arc surface, and a back of the blade protrudes locally, so that a flow channel between the back of the blade and a working surface of its adjacent blade is narrowed locally, forming a throat structure. An outlet of the shrouded impeller is provided with the stator and the rotor, and the stator is located at an outer edge of the front cover plate and fixed on an inner wall of a volute. The rotor is mounted on the rear cover plate.

Two-stage cavitation generator for organic wastewater treatment

The present disclosure discloses a manufacturing method and a manufacturing device for an interconnection piece. The manufacturing method comprises providing a solder strip, and performing forming treatment on the solder strip to obtain a plurality of structural solder strips; and providing a flexible insulating substrate, and compounding the plurality of structural solder strips on the flexible insulating substrate at intervals to obtain the interconnection piece. Each structural solder strip is provided with two soldering portions and a connecting portion located between the two soldering portions, and the connecting portion is respectively connected to the two soldering portions; at least a part of the connecting portion is located on the flexible insulating substrate, and the two soldering portions extend out of the flexible insulating substrate.

Manufacturing method and manufacturing apparatus for interconnection member

Reducing an average give-away rate of a weighing device by determining a weight of a product of a weighing device that includes an article, determining one or more conditions of an environment of the weighing device, determining a state of the environment of the weighing device, wherein the state relates to an average give-away rate of the environment of the weighing device, determining a reward value for the state of the environment of the weighing device, wherein the reward value is based at least in part on the weight of the product, and generating a set of parameters for the weighing device based at least in part on the environment, the state, and the reward.

Adjusting parameters of weighing device for reducing average giveaway rate when packaging an article

A method, computer program product, and computer system for repairing a Dockerfile. Library versions containing initial version numbers of libraries are extracted from the Dockerfile. A Monte Carlo tree search (MCTS) is executed, using the extracted library versions as input, which generates a tree that includes multiple levels populated with noses. Each node in a level represents the generic library name of a library version in the Dockrerfile and an associated randomly selected version number. At least one of the randomly selected version numbers associated with at least one node in a level differs from the initial version number associated with a versionf. A best successful installation path is selected from the at least one successful installation path. The Dockerfile is repaired by inserting randomly selected version numbers into Dockerfile as replacements for some of the initial version numbers.

Modification of a Dockerfile to repair vulnerabilities existing in the Dockerfile

A gear-hydraulic-rhombic pyramid integrated multi-mode hybrid transmission device includes an input assembly, a hydraulic transmission mechanism, a front planetary gear mechanism, a rhombic pyramid-type continuously variable transmission mechanism, a rear planetary gear mechanism, an output assembly, a clutch assembly, and a brake assembly. The clutch assembly connects an output end of the input assembly to an input end of the hydraulic transmission mechanism and an input end of the front planetary gear mechanism. The clutch assembly connects an output end of the hydraulic transmission mechanism to the front planetary gear mechanism and the rear planetary gear mechanism. The clutch assembly connects the front planetary gear mechanism, the rhombic pyramid-type continuously variable transmission mechanism, the rear planetary gear mechanism, and the output assembly in sequence. The clutch assembly and the brake assembly provide a continuous transmission ratio between the input assembly and the output assembly.

Gear-hydraulic-rhombic pyramid integrated multi-mode hybrid transmission device

The present disclosure relates to the technical field of antibody drugs, and in particular, to an anti-CD47 antibody or an antigen-binding fragment thereof, a pharmaceutical composition comprising the anti-CD47 antibody or the antigen-binding fragment thereof, and applications thereof. The anti-CD47 antibody or the antigen-binding fragment thereof has significant antitumor activity and high affinity with human CD47 protein, can eliminate the capability of SIRPa to bind to CD47 on a surface of a cell, and does not have significant hemoagglutination activity and thus can be applied to the preparation of an anti-tumor drug.

Anti-CD47 antibody and application thereof

Growing community of inventors

Jiangsu, China

Yong Wang