Korea Institute of Science and Technology

Yong Sup Lee

Hokoon Park

Jae Yeol Lee

Sun Ho Jung

Eun-Rhan Woo

Hyoung Ja Kim

Ki Hong Nam

Dae Hwan Suk

Hyewhon Rhim

Chang Bae Jin

Changbae Jin

Jungsook Cho

Min Jeoung Son

Chang Soo Yook

Mijeong Park

Yunaaon Song

The present invention relates to anextract, a fraction thereof and the active compounds isolated therefrom, which are effective for the treatment, prevention and improvement of hyperuricemia or gout. Theextract, the fraction thereof and 6'-O-caffeoylampelopsisionoside, 6&#x2032;-O-caffeoylroseoside, 6&#x2032;-O-caffeoylsonchuinoside C, 6&#x2032;-O-caffeoyldihydrosyringin and glehnoside as the active compounds isolated from the fraction according to the present invention have substantial effect of inhibiting production of uric acid and decreasing its concentration. Accordingly, theextract, the fraction thereof and the active compounds isolated therefrom the fraction according to the present invention can be effectively used as an active ingredient of a drug, health food, etc. for the treatment, prevention and improvement of such as hyperuricemia or gout, which are diseases induced by increased level of uric acid.

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An ethyl acetate extract of-and compounds isolated therefrom for preventing and treating brain diseases such as Alzheimer's disease, stroke and Parkinson's disease, cell and tissue damage caused by ischemia, or cardiovascular system disease such as myocardial infarction.

The present invention relates to 3,4-dihydroquinazoline derivatives as T-type calcium channel blockers and a method of preparing the same. The present invention further relates to a composition comprising the same. The composition comprising the 3,4-dihydroquinazoline derivatives of the present invention can be effectively used for preventing and treating angina pectoris, high blood pressure, myocardial disease, pain and epilepsy by blocking the T-type calcium channel.

3,4-dihydroquinazoline derivatives as T-type calcium channel blockers and method of preparing the same

A 3-ammoniopropenyl cephalosporin of the following formula (I): ##STR1## wherein P is hydroxylated alicyclic or aliphatic amines such as meso-3,4-dihydroxy-1-methylpyrrolidine, (3S,4S)-3,4-dihydroxy-1-methylpyrrolidine, (3R,4R)-3,4-dihydroxy-1-methylpyrrolidine, rac-3,4-trans-dihydroxy-1-methylpyrrlidine, (2S,4R)-4-hydroxy-1-methyl-2-pyrrolidinemethanol, N-methyl-bis(2-hydroxyethyl)amine, 3,4-cis-dihydroxy-1-methylpiperidine, 3,4-trans-dihydroxypiperidine, 4-hydroxy-1-methylpiperidine, 2-hydroxymethyl-1-methylpiperidine, or tropine, or a pharmaceutically acceptable salt thereof, exhibits good anti-bacterial activities against a wide variety of Gram-positive and Gram-negative bacteria; and a process for the preparation thereof.

3-ammoniopropenyl cephalosporin compounds as antibacterial agents and

Intermediate compounds represented as formula (I) useful for the synthesis of 16-phenoxy-prostatrienoic acid derivatives and a preparing method thereof are disclosed. ##STR1## wherein R is tetrahydropyranyl, tetrahydrofuranyl, 2-ethoxyethyl, t-butyldimethylsilyl, triisopropylsilyl or triethylsilyl group; R.sup.1 and R.sup.2 are independently hydrogen or ester-forming group; P is hydrogen, trimethylsilyl or tri-n-butyltin; and wavy line means epi-stereoisomeric mixture.

Intermediates for the synthesis of 16-phenoxy-prostatrienoic acid

3-ammoniopropenyl cephalosporin compounds as antibacterial agents

Quaternary ammoniocephalosporins of formula(I) wherein Q.dbd.CH or N, P.dbd.hydroxylated amine or hydroxylated heterocyclylamines including N-methyl-bis(2-hydroxyethyl)amine, rac-3,4-trans-dihydroxy-1-methylpyrrolidine, (3S, 4S)-3,4-dihydroxy-1-methylpyrrolidine, (3R,4R)-3,4-dihydroxy-1-methylpyrrolidine, meso-3,4-dihydorcy-1-methylpyrrolidine, (2S, 4R)-4-hydroxy-1-methyl-2-pyrrolidinemethanol 3,4-cis-dihydroxy-1-methylpiperidine, 3,4-trans-dihydroxy-1-methylpiperidine, or tropine, and preparation methods are disclosed. ##STR1##

Cephalosporin compounds and processes for preparing thereof

Intermediate compounds represented as formula (I) useful for the synthesis of 16-phenoxy-prostatrienoic acid derivatives and a preparing method thereof are disclosed. ##STR1## wherein R is tetrahydropyranyl, tetrahydrofuranyl, 2-ethoxyethyl, 3-t-butyldimethylsilyl triisopropylsilyl or triethylsilyl group; R.sup.1 and R.sup.2 are independently hydrogen or ester-forming group; P is hydrogen, trimethylsilyl or tri-n-butyltin; and wavy line means epistereoisomeric mixture.

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Seoul, South Korea

Yong Sup Lee