Amtixbio Co., Ltd.

Nutrex Technology Co., Ltd.

Yong-Sun Bahn

Jong Hyun Park

Ji Won Choi

Kyung-Tae Lee

Ki Duk Park

Seul Ki Yeon

Eunji Cheong

Siwon Kim

Ye Rim Lee

Joohyeon Hong

Hyeon Ji Kim

Jong-Seung Lee

Jong-seung Lee

Young-Joon Ko

Shin-Ae Maeng

Kwang Woo Jung

Gyu Bum Kim

The present invention relates to a derivative compound in which a biphenyl group is introduced into an aminoalkanoic acid, a stereoisomer thereof, or a pharmaceutically acceptable salt thereof. The compound of the present invention exhibits excellent antifungal and fungicidal effects. Furthermore, the compound of the present invention exhibits a synergistic effect when used in combination with a conventional antifungal agent. Furthermore, the compound of the present invention provides broad-spectrum antifungal activity against a wide range of fungal pathogens. Therefore, the compound of the present invention may be widely used in fields requiring treatment with antifungal or fungicidal agents against human pathogenic fungi and animal pathogenic fungi, and phytopathogenic fungi.

Method for preparing aminoalkanoic acid derivative containing biphenyl group

Aminoalkanoic acid derivative containing biphenyl group and use of the same

Pharmaceutical composition comprising aminoalkanoic acid derivative containing biphenyl group

Aminoalkanoic acid derivative containing biphenyl group and antifungal pharmaceutical composition comprising the same

Provided herein are uses of genes for HOG, Ras and cAMP signal transduction pathways to treat fungal infection. To regulate the HOG pathway of, roles of SSK1, TCO2, SSK2, PBS2, HOG1, ENA1 and NHA1 genes were investigated to find that a biosynthesis level of ergosterol is increased when these genes are inhibited. When the genes are inhibited, a large amount of ergosterol is distributed on a fungal cell membrane. Accordingly, since there are many working points of an ergosterol-binding antifungal agent, an efficiency of the ergosterol-binding antifungal agent can be considerably improved. To regulate the Ras and cAMP pathways of, roles of RAS1, RAS2, CDC24, GPA1, CAC1, ACA1, PKA1, HSP12 and HSP122 genes were investigated to find that a sensitivity to a polyene- or azole-based drug is increased when these genes are inhibited. Therefore, an antifungal pharmaceutical composition including an inhibitor against the gene or protein encoded by the same can be used as an excellent combined antifungal agent which can reduce a conventional amount of an antifungal agent used and increase an efficiency.

Use of the genes in the Hog, Ras and cAMP pathway for treatment of fungal infection

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Seoul, South Korea

Yong-Sun Bahn