Hainan Hdeton Science and Technology Co., Ltd.

China University of Mining and Technology

Meridian Laboratories, Inc.

Yong Ren

Shuqin Yu

Jianfeng Gao

Ling Wu

Xing Zhang

Zhencai Zhu

Gongbo Zhou

Guohua Cao

Yuxing Peng

Mingquan Qiu

Wei Li

Xiaodong Sun

Xueqin Ma

A fracture detection system and method for a dumbbell pin of a scraper conveyor. The system comprises a scraper conveyor, a wireless ranging apparatus (), a wireless communication device, a support controller and a monitoring center. The wireless ranging apparatus () is mounted on a ramp plate ledge of a scraper conveyor chute (), and has a laser range finder and a reflection target plate () for detecting a relative displacement between any two adjacent chutes. The wireless communication device realizes communication between the wireless ranging apparatus () and the support controller, and transmits the displacement of the laser range finder to the support controller in a wireless transmission manner. The support controller controls an action of the scraper conveyor chute (). A monitoring center is electrically connected to the support controller, and can perform storage processing on relative displacement data of any adjacent chutes. In the method, by taking a relative displacement value between adjacent chutes as a reference, whether a fracture fault occurs in a dumbbell pin is judged, the position of the fractured dumbbell pin can be accurately determined, and a support controller controls a chute action, thereby having a high promotion and usage value.

Fracture detection system and method for dumbbell pin of scraper conveyor

Provided is a breakage detection system and method for a scraper conveyor, wherein a speed measurement device of the detection system and a sprocket assembly of the scraper conveyor are coaxially installed. Encoders are installed on speed measurement gears of the speed measurement device. An output end of the speed measurement device is connected to an input end of a programmable logic controller (PLC). An output end of the PLC is electrically connected to an automatic alarm device and a digital display module. A power supply module is used for supplying power to the whole system.

Breakage detection system and method of chains of a scraper conveyor

A docetaxel inclusion complex having improved water-solubility (up to 15 mg/ml) and stability (stability constant Ka=2056 M-13051 M), comprises docetaxel and hydroxypropyl-beta-cyclodextrin and/or sulfobutyl-beta-cyclodextrin in a ratio of 1:10-150. The method includes steps as follows: docetaxel dissolved in ethanol is added into water solution of cyclodextrin via stirring, until docetaxel is completely dissolved; said solution is filtered in 0.2-04 &#x3bc;m microporous membrane then ethanol is removed through reduced pressure to obtain the inclusion complex in a liquid form; or ethanol, followed by water is removed through reduced pressure, then dried to obtain the inclusion complex in a solid form.

Pharmaceutical composition containing docetaxel-cyclodextrin inclusion complex and its preparing process

A docetaxel inclusion complex having improved water-solubility (up to 15 mg/ml) and stability (stability constant Ka=2056M-13051M), comprises docetaxel and hydroxypropyl-beta-cyclodextrin and/or sulfobutyl-beta-cyclodextrin in a ratio of 1:10-150. The method includes steps as follows: docetaxel dissolved in ethanol is added into water solution of cyclodextrin via stirring, until docetaxel is completely dissolved; said solution is filtered in 0.2-04 &#x3bc;m microporous membrane then ethanol is removed through reduced pressure to obtain the inclusion complex in a liquid form; or ethanol, followed by water is removed through reduced pressure, then dried to obtain the inclusion complex in a solid form.

A pharmaceutical composition comprising cyclodextrin/paclitaxel inclusion, which consists of paclitaxel, cyclodextrin and a pharmaceutically acceptable excipient, wherein the mass ratio of the paclitaxel to cyclodextrin is 1:10-150, the said cyclodextrin is hydroxylpropyl-sulfobutyl-7-&#x3b2;-cyclodextrin, or sulfobutylether-7-&#x3b2;-cyclodextrin, or their mixture; the stability constant of the cyclodextrin/paclitaxel inclusion is Ka=5396M&#x2212;1&#x2212;1412M&#x2212;1. The preparation method of the pharmaceutical composition is as follow: (a) A solution of cyclodextrin is added dropwise to a solution of paclitaxel in ethanol. (b) The resulting mixture is filtered through microporous membrane of 0.2-0.4 &#x3bc;m after being dissolved. (c) Ethanol is removed under reduced pressure to give a liquid inclusion which has the ethanol level of less than 2%, or alternatively water is also removed under reduced pressure, the resulting product is dried giving a solid inclusion.

Pharmaceutical composition comprising cyclodextrin paclitaxel inclusion and preparation method thereof

Hydroxypropyl-sulfobutyl-&bgr;-cyclodextrin, the preparation method, analytical method, and the pharmaceutical application thereof. The hydroxypropyl-sulfobutyl-&bgr;-cyclodextrin is a derivate of cyclodextrin which is substituted by hydroxypropyl group and sulfobutyl group: n-(2,3,6-O-2-hydroxypropyl)-m-(2,3,6-O-sulfobutyl)-&bgr;-cyclodextrin. The number of substituent groups per mole cyclodextrin is n hydroxypropyl groups and m sulfobutyl groups. 'n' represents the average substituent degree of hydroxypropyl groups; 'm' represents the average substituent degree of sulfobutyl groups; &#x201c;n+m=z&#x201d; is the gross average substituent degree, in which n is a random integer chosen from 1,2,3,4,5,6,7,8,9; m is a random integer chosen from 1,2,3,4,5,6,7,8,9; and the gross average substituent degree z is a random integer chosen from 2,3,4,5,6,7,8,9,10. The present invention shows low haemolysis and low toxicity.

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Jiangsu, China

Yong Ren