H. Lee Moffitt Cancer Center and Research Institute, Inc.

Chongqing Zein Pharmaceutical Co., Ltd

Sichuan University

Chongqing Zen Pharmaceutical Co., Ltd.

Chongqing Zhien Pharmaceutical Co., Ltd.

Yong Qin

Hao Song

Rongshi Li

Yan Liu

Chunwei Cheng

Said M Sebti

Xiaolin Wang

Dan Zhang

Shan Huang

Zongyin Qiu

Lirong Xu

Min Zhang

Bao Ding

Qiu Chen

Xianglin Deng

Xuan Zhou

Guofeng Yu

Ke Wang

Yongpeng Xia

Marinopyrrole derivatives and methods for their synthesis and use are described herein. Novel cyclic and symmetric marinopyrroles with triazole substituents having antibacterial activity against resistant bacterial strains, such as MRSA are introduced. Also provided are methods of using the compounds for treating or preventing cancer and/or microbial infections.

Marinopyrrole derivatives and methods of making and using same

Symmetrical marinopyrrole derivatives are disclosed herein, as is a synthetic route for producing these compounds. Also disclosed are methods of using symmetrical marinopyrrole derivatives to treat bacterial pathogens, like MRSE, MSSA and MRSA.

Symmetrical marinopyrrole derivatives as potential antibiotic agents

This invention discloses a novel compound with the structure of formula I, or pharmaceutically acceptable salts or solvates thereof. In addition, the invention further discloses a method for preparing the compound, a pharmaceutical composition containing the compound, and use thereof in the preparation of a hypoglycemic medicament. 

Ecdysterone synthesis derivative, preparation method and use thereof

The present invention relates to a method for the preparation of (3S,4S)-3-hexyl-4-((R)-2-hydroxytridecyl)-oxetan-2-one and a product of the method. The method includes the following steps: a) reducing a substance represented by formula (II) to obtain a substance represented by formula (III), and then oxidizing the substance represented by formula (III) to form a substance represented by formula (IV); b) acylating n-octanoic acid to obtain n-octanoyl chloride using thionyl dichloride, then condensing the obtained n-octanoyl chloride with 2-mercapto-pyridine under basic condition to form a substance represented by formula (V), and then converting the substance represented by formula (V) to a substance represented by formula (VI); c) reacting the substance obtained in the step a) with the substance obtained in the step b) under catalytic condition of Lewis acid to generate a substance represented by formula (VII), and then reacting with a Lewis acid. The meanings of the signs in these formulas are the same as those in the description. 

Preparation method of (3S,4S)-3-hexyl-4-((R)-2-hydroxytridecyl)-oxetan-2-one and the product of that method

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Chongqing, China

Yong Qin