Shanghai Jiao Tong University

Shanghai Nature Standard R&d and Biotech Co., Ltd

Shanghai Standard Technology Co., Ltd.

Shanghai Founder Biomed R&d Co., Ltd.

Yong Qian

Xiuchen Jiang

Yadong Liu

Yue Hu

Jiapeng Li

Gehao Sheng

Xiaolei Xie

Yun Hu

Zhiqin Ji

Xiaoya Zhou

Shaopeng Wei

Jiejie Dai

Tianpei Xie

Jiamei Liu

A method for detecting and locating faulty line on the distribution network circuit based on full waveform information, which uses the current data on the fault occurrence and whole-process operation of the compensation device to effectively solve such common problems as low fault current, poor reliability and low sensitivity in case of single-phase grounding fault to the low-current system through precise GPS synchronization. It improves the sensitivity and reliability of the grounding fault detection, which does not interfere with the system and is applicable to high-resistance grounding.

Method for locating distribution network circuit fault based on full waveform information

Disclosed are a use of a methylacryloyl benzimidazolone derivative, an optical isomer or a pharmaceutically acceptable salt or prodrug thereof in the preparation of: (a) a pharmaceutical composition or reagent for down-regulating the activity of PI3K/Akt pathways; (b) a pharmaceutical composition or reagent for treating or inhibiting a tumour; and/or inhibiting tumour cell growth; and/or (c) a pharmaceutical composition or reagent for blocking the cell cycle. The compounds involved in the present invention can down-regulate the level of Akt phosphorylation in P13K/Akt signaling pathways, and the functional effects of the compounds are equivalent to those of a novel small-molecular targeting drug MK2206; while the research at the cellular level has found that the methylacryloyl benzimidazolone derivatives represented by FD1 have a good proliferation inhibiting effect on tumour cells. What is different from MK2206 is that FD1 has better effects on a PTEN deleted cell.

Methylacryloyl benzimidazolone derivative and anti-tumour use thereof

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Shanghai, China

Yong Qian