Georgetown University

Duke University

Yong Liu

Milton L Brown

Mikell Paige

Kenneth J Kellar

Yingxian Xiao

Edward D Levin

Amir H Rezvani

Mikell A Paige

Disclosed are heterocyclic compounds that are ligands for nicotinic acetylcholine receptors. The compounds are useful for treating a mammal suffering from any one of a range of therapeutic indications, including Alzheimer's disease, Parkinson's disease, dyskinesias, Tourette's syndrome, schizophrenia, attention deficit disorder, anxiety, pain, depression, obsessive compulsive disorder, chemical substance abuse, alcoholism, memory deficit, pseudodementia, Ganser's syndrome, migraine pain, bulimia, obesity, premenstrual syndrome or late luteal phase syndrome, tobacco abuse, post-traumatic syndrome, social phobia, chronic fatigue syndrome, premature ejaculation, erectile difficulty, anorexia nervosa, disorders of sleep, autism, mutism, trichotillomania, and hypothermia.

2-halo-5-alkynyl-pyridyl nicotinic ligands

2,5-disubstituted-pyridyl nicotinic ligands, and methods of use thereof

Growing community of inventors

Rockville, MD, United States of America

Yong Liu