Codexis, Inc.

Yong Koy Bong

Steven James Collier

Derek J Smith

Shiwei Song

Jagadeesh Mavinahalli

Michael Vogel

Oscar Alvizo

Emily Mundorff

Wan Lin Yeo

Behnaz Behrouzian

Anupam Gohel

Michael A Crowe

Naga K Modukuru

Jeffrey C Moore

Haibin Chen

Fabien Louis Cabirol

Yang Hong

Martina Quintanar-Audelo

Tao Li

Anupam Gohel Prafulchandra

Xiyun Zhang

Jovana Nazor

Vesna Mitchell

Benjamin Mijts

Michael D Clay

Jun Zhu

Jian Ding

Hong Yang

Derek Smith

Steven J Collier

The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents.

Biocatalysts and methods for hydroxylation of chemical compounds

The present disclosure relates to non-naturally occurring polypeptides useful for preparing Ezetimibe, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

Biocatalysts for ezetimibe synthesis

Biocatalysts for Ezetimibe synthesis

Engineered proline hydroxylase polypeptides and methods

Engineered proline hydroxylase polynucleotides and methods

Methods for hydroxylyation of chemical compounds

The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents. The present disclosure provides engineered proline hydroxylase biocatalysts, polynucleotides encoding the biocatalysts, methods of their preparation, and processes for preparing hydroxylated compounds using these engineered biocatalysts.

Engineered proline hydroxylase polypeptides

The present disclosure relates to non-naturally occurring monooxygenase polypeptides useful for preparing prazole compounds, polynucleotides encoding the polypeptides, and methods of using the polypeptides.

Synthesis of prazole compounds

The present disclosure relates to engineered ketoreductase polypeptides and uses thereof for the preparation of &#x3b1;-chloroalcohols from &#x3b1;-chloroketones. Also provided are polynucleotides encoding the engineered ketoreductase polypeptides and host cells capable of expressing the engineered ketoreductase polypeptides.

Ketoreductase-mediated stereoselective route to alpha chloroalcohols

Growing community of inventors

Singapore, Singapore

Yong Koy Bong