Verdia Inc.

Pioneer Hi-bred International, Inc.

E.i. Dupont De Nemours and Company

E. I. Du Pont De Nemours

University of Iowa Research Foundation

Pioneer Hi-bred Int'l Inc.

Maxygen, Inc.

Fondazione Telethon

Dsm Sinochem Pharmaceuticals Netherlands B.v.

Roger Kemble

Christina Ivy

Billy Fred Mccutchen

Lorraine J. Giver

Nicholas B. Duck

Jeremy Minshull

Yong Hong Chen

Jeremy S Minshull

Phillip A Patten

Nicholas B Duck

Lorraine Joan Giver

Linda A Castle

Dan Siehl

Rebecca Lynne Gorton

Cristina Ivy

Billy Fred McCutchen

Beverly L Davidson

Willem P C Stemmer

Stephane J Jenne

Anke Krebber

Claus M Krebber

Alberto Auricchio

Sun Ai Raillard

Luis Tecedor

Claus Krebber

Lourina Madeleine Raamsdonk

Matthew Tobin

Charlene To La Ching

Xiaodong Gao

Dick Schipper

Roelof Ary Lans Bovenberg

Lorraine J Giver

Yan Chen

The present disclosure provides targeting peptides and vectors containing a sequence that encodes targetting peptides that deliver agents, to the eye. The present inventors have discovered peptides that function to target agents, such as viral vectors, to ocular cells. The present disclosure describes a method to utilize these novel peptides to direct, for example, viral capsids to the cell type of interest. In this instance, ocular cells (such as retinal cells) are targeted by the identified peptides. Vectors harboring capsid proteins modified to include such peptides can be used to provide therapeutic agents to the eye.

Methods and compositions for treating genetic eye diseases

The present disclosure provides methods of treating a disease or delivering a therapeutic agent to a mammal comprising administering to the mammal's cisterna magna and/or ventricle an rAAV particle containing a vector comprising a nucleic acid encoding a therapeutic protein inserted between a pair of AAV inverted terminal repeats in a manner such that cells with access to the cerebrospinal fluid (CSF) express the therapeutic agent and in certain embodiments secretes the therapeutic agent into the CSF for distribution to the brain.

Methods and compositions for treating brain diseases

The present disclosure provides targeting peptides and vectors containing a sequence that encodes targeting peptides that deliver agents to the brain.

Novel proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are novel polynucleotides capable of encoding these proteins, compositions that include one or more of these novel proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these novel compounds, diversification methods involving the novel compounds, and methods of using the compounds. Some of the novel methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.

Glyphosate-N-acetyltransferase (GAT) genes

Proteins are provided herein, including proteins capable of catalyzing the acetylation of glyphosate and other structurally related proteins. Also provided are polynucleotides capable of encoding these proteins, compositions that include one or more of these proteins and/or polynucleotides, recombinant cells and transgenic plants comprising these compounds, diversification methods involving the compounds, and methods of using the compounds. Some of the methods and compounds provided herein can be used to render an organism, such as a plant, resistant to glyphosate.

Growing community of inventors

Foster City, CA, United States of America

Yong Hong Chen